June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
Clinical Characteristics of Vogt-Koyanagi-Harada Disease with Choroidal Folds
Author Affiliations & Notes
  • Kouhei Hashizume
    Ophthalmology, Iwate Medical University, Morioka, Japan
  • Yutaka Imamura
    Ophthalmology, Teikyo University School of Medicine, Mizonokuchi Hospital, Kawasaki, Japan
  • Takamitsu Fujiwara
    Ophthalmology, Iwate Medical University, Morioka, Japan
  • Shigeki Machida
    Ophthalmology, Iwate Medical University, Morioka, Japan
  • Masahiro Ishida
    Ophthalmology, Teikyo University School of Medicine, Mizonokuchi Hospital, Kawasaki, Japan
  • Daijiro Kurosaka
    Ophthalmology, Iwate Medical University, Morioka, Japan
  • Footnotes
    Commercial Relationships Kouhei Hashizume, None; Yutaka Imamura, None; Takamitsu Fujiwara, None; Shigeki Machida, None; Masahiro Ishida, None; Daijiro Kurosaka, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 5380. doi:https://doi.org/
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    • Get Citation

      Kouhei Hashizume, Yutaka Imamura, Takamitsu Fujiwara, Shigeki Machida, Masahiro Ishida, Daijiro Kurosaka; Clinical Characteristics of Vogt-Koyanagi-Harada Disease with Choroidal Folds. Invest. Ophthalmol. Vis. Sci. 2013;54(15):5380. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

To investigate the clinical characters of Vogt-Koyanagi-Harada disease (VKH) patients with choroidal folds.

 
Methods
 

Choroidal folds in eyes with VKH were observed using enhanced depth imaging optical coherence tomography. Clinical characteristics associated with the presence of choroidal folds were investigated.

 
Results
 

Among 30 patients with VKH (mean age: 49 years), 15 patients showed choroidal folds at acute phase. The age at onset of the patients with choroidal folds was higher than those without choroidal folds (58.5 ± 11.7 v.s. 38.6 ± 12.9, t test: p = 0.001) Choroidal thickness of the patients with choroidal folds was significantly larger than those without choroidal folds before high-dose steroid therapy (936 ± 160 μm v.s. 811 ± 207 μm, Mann-Whitney U test: p = 0.004) The patients with choroidal folds had smaller choroidal thickness at two weeks and one month after high-dose steroid therapy than those without choroidal folds. (362 ± 131 μm v.s. 547 ± 219 μm, Mann-Whiteny U test: p = 0.001, 330 ± 101 μm v.s. 428 ± 143 μm, Mann-Whiteny U test : p = 0.007, respectively)

 
Conclusions
 

VKH patients showing choroidal folds at acute phase appear older and to show thicker choroids than those without.

  
Keywords: 746 uveitis-clinical/animal model • 452 choroid  
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