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Kouhei Hashizume, Yutaka Imamura, Takamitsu Fujiwara, Shigeki Machida, Masahiro Ishida, Daijiro Kurosaka; Clinical Characteristics of Vogt-Koyanagi-Harada Disease with Choroidal Folds. Invest. Ophthalmol. Vis. Sci. 2013;54(15):5380.
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© ARVO (1962-2015); The Authors (2016-present)
To investigate the clinical characters of Vogt-Koyanagi-Harada disease (VKH) patients with choroidal folds.
Choroidal folds in eyes with VKH were observed using enhanced depth imaging optical coherence tomography. Clinical characteristics associated with the presence of choroidal folds were investigated.
Among 30 patients with VKH (mean age: 49 years), 15 patients showed choroidal folds at acute phase. The age at onset of the patients with choroidal folds was higher than those without choroidal folds (58.5 ± 11.7 v.s. 38.6 ± 12.9, t test: p = 0.001) Choroidal thickness of the patients with choroidal folds was significantly larger than those without choroidal folds before high-dose steroid therapy (936 ± 160 μm v.s. 811 ± 207 μm, Mann-Whitney U test: p = 0.004) The patients with choroidal folds had smaller choroidal thickness at two weeks and one month after high-dose steroid therapy than those without choroidal folds. (362 ± 131 μm v.s. 547 ± 219 μm, Mann-Whiteny U test: p = 0.001, 330 ± 101 μm v.s. 428 ± 143 μm, Mann-Whiteny U test : p = 0.007, respectively)
VKH patients showing choroidal folds at acute phase appear older and to show thicker choroids than those without.
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