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Jun-Sub Choi, Choun-Ki Joo; The effect of sulindac liposome on inflammation induced corneal neovascularization. Invest. Ophthalmol. Vis. Sci. 2013;54(15):5401.
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To investigate the effect of topical sulindac liposome on inflammatory induced corneal neovascularization.
Sprague-Dawley male (250g) rats were used for alkali burn model. After alkali injuries using 1 N NaOH, the control group (n=10) received topical PBS four times a day for 2 days. The other study groups received topical sulindac-liposome. The corneal neovascularization were evaluated using slit lamp biomicroscopy. And tissue sections were analyzed for inflammatory cell infiltration. Inflammatory cells were confirmed by immunohistochmistry for F4/80.
The sulindac liposome inhibited corneal neovasculariztion and inflammatory response after corneal injury. In light microscopic findings, the corneal thickness was increased and many polymorphonuclear leukocytes infiltrated in the corneal stroma in the control group. In immunohistochemical study, in sulindac-liposome treated group, the F4/80 positive cells were detected lower than control group (p<0.05, respectively).
The sulindac is anti-inflammatory drugs. The topical sulindac liposome has beneficial effect on inflammatory induced corneal neovascularization. Supported: This study was supported by a grant of the Korean Health Technology R&D Project, Ministry for Health & Welfare, Republic of Korea. (A092258)
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