June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
Extended Soft Bandage Contact Lenses Therapy for Ocular Graft-Versus-Host Disease
Yichen Sun; Yoshihiro Inamoto; Joseph Sheehan; Peng Li; Ruikang Wang; Stephanie Lee; Tueng Shen
Author Affiliations & Notes
  • Yichen Sun
    Ophthalmology, University of Washington, Seattle, WA
    Graduate Institute of Clinical Medicine, National Taiwan University, Taipei, Taiwan
  • Yoshihiro Inamoto
    Fred Hutchinson Cancer Research Center, Seattle, WA
  • Joseph Sheehan
    Ophthalmology, University of Washington, Seattle, WA
  • Peng Li
    Bioengineering, University of Washington, Seattle, WA
  • Ruikang Wang
    Ophthalmology, University of Washington, Seattle, WA
    Bioengineering, University of Washington, Seattle, WA
  • Stephanie Lee
    Fred Hutchinson Cancer Research Center, Seattle, WA
  • Tueng Shen
    Ophthalmology, University of Washington, Seattle, WA
    Bioengineering, University of Washington, Seattle, WA
  • Footnotes
    Commercial Relationships Yichen Sun, None; Yoshihiro Inamoto, None; Joseph Sheehan, None; Peng Li, None; Ruikang Wang, National Institutes of Health (F), W.H. Coulter Foundation Translational Research Partnership Program (F), Research to prevent blindness (F), Oregon Health & Science University (P), University of Washington (P); Stephanie Lee, None; Tueng Shen, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 5440. doi:
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      Yichen Sun, Yoshihiro Inamoto, Joseph Sheehan, Peng Li, Ruikang Wang, Stephanie Lee, Tueng Shen; Extended Soft Bandage Contact Lenses Therapy for Ocular Graft-Versus-Host Disease. Invest. Ophthalmol. Vis. Sci. 2013;54(15):5440.

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Abstract

Purpose: Graft-versus-Host Disease (GVHD) is a major complication of allogenic tissue/hematopoietic stem cell transplantation. 60% of GVHD patients have ocular involvement with significant compromise in quality of life due to ocular symptoms (such as severe photophobia, pain and decreased visual acuity). We report the outcome of extended soft bandage contact lens (BCL) treatment for symptomatic relief and ocular surface protection in GVHD patients.

Methods: Prospective Phase II clinical trial. IRB approval of the clinical protocol was first obtained. Patients (age 18-99) with diagnosis of chronic GVHD as defined by the NIH criteria and ocular symptoms of NIH eye score 2 or greater are selected for the study with written informed consent. Extended soft bandage contact lenses were applied to the GVHD-affected eyes with antibiotic coverage during the two week period. Ocular exam, anterior segment OCT (AS-OCT) and patient survey are obtained. Patients are followed for one month. Clinical outcomes, such as visual acuity, corneal presentations (abrasion, punctate epithelial erosion and filament) are correlated with symptomatic survey findings as well as OCT findings.

Results: 20 patients with ocular GVHD will be included in the study. Ocular manifestations of GVHD observed by clinical exam are also characterized by AS-OCT. First six including patients are all shown with improving symptoms/signs and without any occurrence of complications. Symptomatic changes with the BCL therapy are correlated with ocular exams as well as AS-OCT.

Conclusions: BCL can offer significant symptomatic relief for patients with ocular GVHD. AS-OCT can be a feasible method to characterize pathological changes related to ocular GVHD. In addition, wearing of extended soft bandage contact lens can diminish the attrition of cornea from eyelid and provide symptomatic relief for patients with ocular GVHD.

Keywords: 477 contact lens • 486 cornea: tears/tear film/dry eye  
© 2013, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2024 Association for Research in Vision and Ophthalmology.
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