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Shaoying Tan, Nafees Baig, Clement Tham; Diurnal Non-Clinic-Measured Intraocular Pressure Profile in Primary Angle-Closure Glaucoma Patients. Invest. Ophthalmol. Vis. Sci. 2013;54(15):5619.
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Single intraocular pressure (IOP) measurement in clinic cannot reflect IOP fluctuation and its peak level during daily life. In this study, the diurnal IOP profiles in clinic and non-clinic environments were investigated and compared in patients with primary angle-closure glaucoma (PACG).
Twenty-six eyes from 26 PACG patients under regular medical treatments were included in this study. IOP was measured by Rebound self-measured tonometry daily at 8:00, 12:00, 16:00, 20:00 and 24:00 for 1 week under patients’ routine activities. Goldmann applanation tonometer was used to verify the IOP measurement on the same tested eye in clinic on the recruitment day, the middle of the week, and the last day.
Variable patterns of diurnal IOP profiles were observed among the PACG patients under medical treatment. Their IOPs were well controlled within 21 mmHg (range: 5.8-20.93mmHg). The mean of diurnal IOP profile shows highest in the morning and gradually decreases throughout the day. The frequency of peak IOP occurred in the early morning was 44% and most lowest IOP happened in the late evening was 36%. The differences between mean of diurnal non-clinic IOP and clinic-measured IOP were 1.28 ± 0.86 mmHg (mean ± S.D.). The 95% limits of agreement were -6.20 - 3.64 mmHg.
Diurnal IOP was stably maintained in most of PACG patients under medical treatments. Highest IOP was observed in the morning. The peak diurnal IOP in non-clinic environment could be predicted from the mean clinic IOPs.
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