June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
Epithelial Basement Membrane Dystrophy: A Study with in vivo Confocal Microscopy and High-Resolution Anterior Segment Optical Coherence Tomography
Author Affiliations & Notes
  • Peter Wu
    Ophthalmology & Vision Sciences, University of California Davis Eye Center, Sacramento, CA
  • Dennis Cortes
    Ophthalmology & Vision Sciences, University of California Davis Eye Center, Sacramento, CA
    Ophthalmology, Universidad Catolica de Chile, Santiago, Chile
  • Jennifer Li
    Ophthalmology & Vision Sciences, University of California Davis Eye Center, Sacramento, CA
  • Michael Chen
    Ophthalmology & Vision Sciences, University of California Davis Eye Center, Sacramento, CA
  • Mark Mannis
    Ophthalmology & Vision Sciences, University of California Davis Eye Center, Sacramento, CA
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 564. doi:
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      Peter Wu, Dennis Cortes, Jennifer Li, Michael Chen, Mark Mannis; Epithelial Basement Membrane Dystrophy: A Study with in vivo Confocal Microscopy and High-Resolution Anterior Segment Optical Coherence Tomography. Invest. Ophthalmol. Vis. Sci. 2013;54(15):564.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

To report the pathological changes of patients with epithelial basement membrane dystrophy (EBMD), the most common hereditary anterior corneal dystrophy, using in vivo confocal microscopy (IVCM) and high-resolution anterior segment optical coherence tomography (AS-OCT).

 
Methods
 

Five patients with EBMD seen in clinical practice were evaluated with a high-resolution spectral-domain AS-OCT (Heidelberg Engineering, Germany) and IVCM using the Heidelberg Retina Tomograph 3 Rostock Cornea Module (Heidelberg Engineering, Germany).

 
Results
 

AS-OCT revealed hyperreflective material in the posterior epithelium and anterior stroma. These findings were correlated with IVCM findings that showed multiple linear and curvilinear hyperreflective structures, corresponding to abnormal epithelial basement membrane extending into the corneal epithelium. Additionally, IVCM revealed hyperreflective deposits in the anterior stroma with signs of activation of anterior keratocytes, intraepithelial microcysts, and clusters of epithelial cells in the tear film.

 
Conclusions
 

The acquisition of high-resolution imaging of the cornea with IVCM and AS-OCT provides new insights into the microstructural characteristics of EBMD and may be useful modalities in elucidating the pathogenesis and natural course of this corneal dystrophy.

 
 
A: slit lamp photo of EBMD B: in-vivo confocal microscopy (IVCM) revealing linear hyperreflective structures corresponding to abnormal epithelial basement membrane extending into the corneal epithelium C: anterior segment OCT (AS-OCT) revealing hyperreflective material in the posterior epithelium and anterior stroma
 
A: slit lamp photo of EBMD B: in-vivo confocal microscopy (IVCM) revealing linear hyperreflective structures corresponding to abnormal epithelial basement membrane extending into the corneal epithelium C: anterior segment OCT (AS-OCT) revealing hyperreflective material in the posterior epithelium and anterior stroma
 
 
A: slit lamp photo of EBMD B: oblique section of in-vivo confocal microscopy revealing an area of fibrosis at the sub-epithelial level C: anterior segment OCT (AS-OCT) demonstrating hyperreflective material in the posterior epithelium and anterior stroma
 
A: slit lamp photo of EBMD B: oblique section of in-vivo confocal microscopy revealing an area of fibrosis at the sub-epithelial level C: anterior segment OCT (AS-OCT) demonstrating hyperreflective material in the posterior epithelium and anterior stroma
 
Keywords: 479 cornea: clinical science • 552 imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • 596 microscopy: confocal/tunneling  
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