June 2013
Volume 54, Issue 15
ARVO Annual Meeting Abstract  |   June 2013
Changes in intraocular pressure measurements and corneal biomechanical properties in eyes with glaucoma using prostaglandin analogues
Author Affiliations & Notes
    Glaucoma, APEC, mexico city, Mexico
  • Oscar Albis-Donado
    Glaucoma, APEC, mexico city, Mexico
  • Jesus Jimenez-Roman
    Glaucoma, APEC, mexico city, Mexico
  • Footnotes
    Commercial Relationships MARIA JOSE MONTERO, None; Oscar Albis-Donado, None; Jesus Jimenez-Roman, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 5651. doi:
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      MARIA JOSE MONTERO, Oscar Albis-Donado, Jesus Jimenez-Roman; Changes in intraocular pressure measurements and corneal biomechanical properties in eyes with glaucoma using prostaglandin analogues. Invest. Ophthalmol. Vis. Sci. 2013;54(15):5651.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: To measure intraocular pressure changes with applanation tonometry (AT), dynamic contour tonometry (DCT) and ocular response analyzer (ORA) in eyes with glaucoma treated with prostaglandin analogues (PGA)

Methods: Intraocular pressure (IOP) was measured using AT, DCT and ORA in 38 glaucoma eyes at baseline and after 3 weeks of treatment with PGA. Baseline mean difference in IOP between tonometers was compared to differences with treatment. Paired samples T test was used for pre and post-treatment comparisons.Central Corneal Thickness (CCT),corneal hysteresis (CH) and corneal resistance factor (CRF) were also measured and analysed using SPSS version 19

Results: Eyes treated with PGAs have lower IOP than at baseline, but each tonometry method shows a different mean amount of IOP lowering. Baseline and treated mean IOPs were different among the 3 tonometers, mean change in IOP as measured by AT was -1.21 mmHg, -1.26 mmHg with DCT and 3 mmHg with ORA . Corneal hysteresis increases an average of 0.83 mmHg while corneal thickness decreases an average of 7.8 microns, corneal resistance factor does not experience a significant change with prostaglandin analogue treatment

Conclusions: AT and DCT seem to be less affected by corneal biomechanical changes induced by PGAs, whereas ORA measurements show an artifactual larger effect of PGAs on IOP; corneal hysteresis increases significantly post treatment with this kind of drugs.Corneal thickness decreases with prostaglandin analogue treatment

Keywords: 465 clinical (human) or epidemiologic studies: systems/equipment/techniques  

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