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MARIA JOSE MONTERO, Oscar Albis-Donado, Jesus Jimenez-Roman; Changes in intraocular pressure measurements and corneal biomechanical properties in eyes with glaucoma using prostaglandin analogues. Invest. Ophthalmol. Vis. Sci. 2013;54(15):5651.
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© ARVO (1962-2015); The Authors (2016-present)
To measure intraocular pressure changes with applanation tonometry (AT), dynamic contour tonometry (DCT) and ocular response analyzer (ORA) in eyes with glaucoma treated with prostaglandin analogues (PGA)
Intraocular pressure (IOP) was measured using AT, DCT and ORA in 38 glaucoma eyes at baseline and after 3 weeks of treatment with PGA. Baseline mean difference in IOP between tonometers was compared to differences with treatment. Paired samples T test was used for pre and post-treatment comparisons.Central Corneal Thickness (CCT),corneal hysteresis (CH) and corneal resistance factor (CRF) were also measured and analysed using SPSS version 19
Eyes treated with PGAs have lower IOP than at baseline, but each tonometry method shows a different mean amount of IOP lowering. Baseline and treated mean IOPs were different among the 3 tonometers, mean change in IOP as measured by AT was -1.21 mmHg, -1.26 mmHg with DCT and 3 mmHg with ORA . Corneal hysteresis increases an average of 0.83 mmHg while corneal thickness decreases an average of 7.8 microns, corneal resistance factor does not experience a significant change with prostaglandin analogue treatment
AT and DCT seem to be less affected by corneal biomechanical changes induced by PGAs, whereas ORA measurements show an artifactual larger effect of PGAs on IOP; corneal hysteresis increases significantly post treatment with this kind of drugs.Corneal thickness decreases with prostaglandin analogue treatment
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