June 2013
Volume 54, Issue 15
ARVO Annual Meeting Abstract  |   June 2013
Are thinner corneas associated with reduced hystersis?
Author Affiliations & Notes
  • Trupti Patil
    Glaucoma, Narayana Nethralaya, Banglore, India
  • Rajesh Sasikumar
    Glaucoma, Narayana Nethralaya, Banglore, India
  • Sathi Devi
    Glaucoma, Narayana Nethralaya, Banglore, India
  • Footnotes
    Commercial Relationships Trupti Patil, None; Rajesh Sasikumar, None; Sathi Devi, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 5655. doi:
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      Trupti Patil, Rajesh Sasikumar, Sathi Devi, Glaucoma; Are thinner corneas associated with reduced hystersis?. Invest. Ophthalmol. Vis. Sci. 2013;54(15):5655.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: To determine the relationship between central corneal thickness (CCT) and corneal biomechanical properties in Asian Indian eyes with glaucoma.

Methods: In this prospective observational comparative study, glaucoma patients on treatment were assigned to two groups based on CCT; CCT< 500μ (group A) and >500μ (group B). Goldman applanation tonometry (GAT) was measured in all using a single calibration checked device. Corneal hysteresis (CH), corneal resistance factor (CRF), corneal-compensated IOP (IOPcc), and Goldmann-correlated IOP (IOPg) were measured using the Ocular Response Analyzer (ORA). The deformation amplitude (DA) of the cornea was measured using the CorVis non-contact tonometer. Pearson’s correlation coefficient was used to evaluate correlation between parameters. Univariate and multivariate regression analysis was used to determine the relationship between the various parameters

Results: A total of 107 eyes (76 patients) were enrolled; 60 eyes had CCT<500μ. Majority had open angle glaucoma (62%). The average CCT of group A was 474.7±18.7 μ compared to that of group B (534.6±24.1 μ) (p<0.01). The average CH (7.29 mm Hg in group A vs 7.68 mmHg in group B, p>0.05) and DA (1.01mm vs 1.04mm, p>0.05) was not significantly different, but CRF (8.34mm Hg vs 9.43 mm Hg) showed significant difference (p=0.03). CH showed a weak positive relationship with CCT in both groups (r=0.22-0.25, p<0.05). Univariate analysis with CH as the dependent variable in group A showed significant association with CCT, IOPcc, CRF and GAT (p<0.05) in group A; only IOPcc and CRF showed association in multivariate analysis.

Conclusions: CH, which measures viscous damping of cornea was not significantly different between the two groups; CH and DA do not appear to be influenced by CCT. CRF was significantly different between the two groups, suggestive of reduced overall resistance in thinner cornea.

Keywords: 568 intraocular pressure • 479 cornea: clinical science • 731 texture  

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