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Dominique Bremond-Gignac, Solange Milazzo; Study Of Ocular Surface impairment in children presenting ongoing dry eye with MGD with Meibomian Gland Analysis. Invest. Ophthalmol. Vis. Sci. 2013;54(15):566. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate in a retrospective study, the ocular surface impairment in children presenting ongoing MGD with an analysis of meibomian glands. Tear film quality is conditionned by meibomian gland production of the lipid layer. Anomaly of this production in children can lead to ocular surface impairment and an evaluation of Meibomian Glands is a key point of the exploration of production function.
Our retrospective study included 12 children (22 eyes evaluated) with a mean age 11yo, range 4 to 17yo, of two groups that presented at ocular consultation. Group a, 6 with ongoing MGD, group b 6 control children who had been tested with no ocular surface impairment. All children underwent a Meibomian Gland Analysis with meibography images with infrared illumination acquired with Cobra system. An evaluation with Phoenix software calculated area of loss of glands. The density of inferior eyelids Meibomian glands had also been evaluated.
In group a, all children presented clinical signs of MGD due to ocular blepharitis or dry eye. In group b no ocular signs of conjunctiva or ocular surface anomalies were found. In group a area loss of meibomian gland was evaluated from 41% to 59%. Density of glands was low. In group b area loss of meibomian gland was evaluated from 10% to 42%. In younger children (4 to 7 yo) density of glands was tight and lenght size shorter.
In children, few data are known about Meibomian Gland development and function. Our study is suitable in children with dry eye for the evaluation of Meibomian Glands and can be a useful tool. A larger study has to be performed for a better understanding of dry eye ocular surface impairment in children.
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