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Ainur Anuar, Yingfeng Zheng, Lei Huang, Baskaran Mani, Carol Cheung, Ching-Yu Cheng, Merwyn Chew, Jodhbir Mehta, Tien Wong, Tin Aung, Singapore Epidemiology of Eye Disease (SEED) Centre, Singapore Eye Research Institute; Curry consumption and high myopia in adults: A possible protective effect. Invest. Ophthalmol. Vis. Sci. 2013;54(15):5705.
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To study the effects of curry consumption on the risk of myopia and high myopia in adults.
Time outdoors has been shown to reduce the risk of myopia, suggesting a possible relationship with vitamin D. A popular spice in Middle Eastern and Asian countries, curcumin, the principle ingredient in curry, is a potent nutritionally derived ligand to the human vitamin D receptor (VDR), its coupling exerting bioeffects. In this cross-sectional, population based study of Singaporean adults of Indian ethnicity, the dietary effects of curry consumption on the risk of adult myopia and high myopia was investigated. From 3400 subjects who underwent a standardized interview, ocular examinations, and ocular biometry, 741 subjects (without prior cataract surgery) were included. Diet was assessed using a semi-quantitative food-frequency questionnaire. Frequency of curry consumption was categorized into: frequent (daily), occasional (at least once a week to once a month) and rarely or never (less than once a month or never). Refractive error was determined via autorefraction, followed by subjective refraction. Emmetropia was defined as spherical equivalent (SE) of -0.5 to +0.5 D dioptre (D), hyperopia as > +0.5 D, myopia as < -0.5 D but not less than -6.0 D, and high myopia < - 6.0 D. Axial length (AL) was determined by partial laser interferometry. As the Spearman correlation coefficient for SE in the left and right eye was high, only right eyes were analyzed.
Out of 741 subjects, 656 reported frequent consumption, 31 occasional, and 54 rarely consumed curry. In univariate analysis, except for education level (P<0.0001), neither axial length, height, presence of cataract, nor the amount of time spent reading and writing were found to be significantly associated with the frequency of curry consumption. Using emmetropes as reference, and adjusting for age, gender, and education level, the odds of high myopia were low and significant in subjects who consumed curry daily (frequent) : odds ratio (OR) of 0.25 , 95% Confidence Interval (95% CI) 0.08 to 0.83, P = 0.023. Curry consumption was however not protective against myopia of less than -6.0 D.
Frequent (daily) consumption of curry may be protective against high myopia in adults.
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