June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
Retinal ganglion cell layer thickness reduces after internal limiting membrane peeling during macular hole surgery
Adil Darugar; Violaine Caillaux; Ali Erginay; Benedicte Dupas; Valerie Krivosic; Julien Perol; Sebastien Bruneau; Alain Gaudric; Pascale Massin; Ramin Tadayoni
Author Affiliations & Notes
  • Adil Darugar
    Department of Ophthalmology, Hôpital Lariboisière, Université Paris Diderot - Sorbonne Paris Cité, AP-HP, Paris, France, Paris, France
  • Violaine Caillaux
    Department of Ophthalmology, Hôpital Lariboisière, Université Paris Diderot - Sorbonne Paris Cité, AP-HP, Paris, France, Paris, France
  • Ali Erginay
    Department of Ophthalmology, Hôpital Lariboisière, Université Paris Diderot - Sorbonne Paris Cité, AP-HP, Paris, France, Paris, France
  • Benedicte Dupas
    Department of Ophthalmology, Hôpital Lariboisière, Université Paris Diderot - Sorbonne Paris Cité, AP-HP, Paris, France, Paris, France
  • Valerie Krivosic
    Department of Ophthalmology, Hôpital Lariboisière, Université Paris Diderot - Sorbonne Paris Cité, AP-HP, Paris, France, Paris, France
  • Julien Perol
    Department of Ophthalmology, Hôpital Lariboisière, Université Paris Diderot - Sorbonne Paris Cité, AP-HP, Paris, France, Paris, France
  • Sebastien Bruneau
    Department of Ophthalmology, Hôpital Lariboisière, Université Paris Diderot - Sorbonne Paris Cité, AP-HP, Paris, France, Paris, France
  • Alain Gaudric
    Department of Ophthalmology, Hôpital Lariboisière, Université Paris Diderot - Sorbonne Paris Cité, AP-HP, Paris, France, Paris, France
  • Pascale Massin
    Department of Ophthalmology, Hôpital Lariboisière, Université Paris Diderot - Sorbonne Paris Cité, AP-HP, Paris, France, Paris, France
  • Ramin Tadayoni
    Department of Ophthalmology, Hôpital Lariboisière, Université Paris Diderot - Sorbonne Paris Cité, AP-HP, Paris, France, Paris, France
  • Footnotes
    Commercial Relationships Adil Darugar, None; Violaine Caillaux, None; Ali Erginay, Novartis (R), Bayer (R), Alimera (C); Benedicte Dupas, Novartis (C); Valerie Krivosic, None; Julien Perol, None; Sebastien Bruneau, None; Alain Gaudric, None; Pascale Massin, Novartis (C), Allergan (C), Fovea Pharmaceutical (C), Fournier Abbott (C); Ramin Tadayoni, Alcon (C), Novartis (C), Allergan (C), DORC (R), Bausch + Lomb (R), FCI-Zeiss (C), Takeda (R), Alimera (R), Bayer (C)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 5766. doi:
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      Adil Darugar, Violaine Caillaux, Ali Erginay, Benedicte Dupas, Valerie Krivosic, Julien Perol, Sebastien Bruneau, Alain Gaudric, Pascale Massin, Ramin Tadayoni; Retinal ganglion cell layer thickness reduces after internal limiting membrane peeling during macular hole surgery. Invest. Ophthalmol. Vis. Sci. 2013;54(15):5766.

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Abstract

Purpose: to investigate the potential effect of internal limiting membrane (ILM) peeling during macular hole (MH) surgery on the retinal ganglion cells layer thickness

Methods: retrospective comparative case series. Twenty-five eyes of 25 consecutive patients who had undergone surgery for full thickness idiopathic MH with anatomical success, and had a Cirrus ® spectral domain optical coherence tomography (SD-OCT): 18 patients had ILM peeling, and 7 patients did not. The thickness of the retinal ganglion cells layer was measured in the treated eye 3 months after surgery and compared to the fellow eye. Measurements were obtained from a 6 x 6 mm Macular Cube (512 x 128 scans), using the automatic Ganglion Cell Analysis program of the Cirrus 6.0 software (Carl Zeiss Meditec, Dublin, CA). The main outcome measure was the change in the retinal ganglion cell layer thickness in each group

Results: Mean retinal ganglion cell layer thickness in fellow eyes was 80,6 ± 8 microns. A thinning of the retinal ganglion cell layer was observed when the ILM was peeled (-9,2 ± 8 microns, p = 0,001), while unchanged in eyes operated without ILM peeling (+0,7 ± 4 microns). The thinning was bigger in the temporal side of the fovea

Conclusions: ILM peeling induces a thinning of the retinal ganglion cell layer in addition to already published dissociation of the nerve fiber layer (DONFL). This ganglion cell loss could be an explanation for the alterations of retinal sensitivity and microperimetry after ILM peeling reported by several authors

Keywords: 586 macular holes • 762 vitreoretinal surgery • 531 ganglion cells  
© 2013, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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