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Silvestro Caputo, Anna Sala-Puigdollers, Hojr Jaberansari, Jane Gray, Yvonne D'Souza, Stephen Charles, Susmito Biswas, David Henson, David McLeod, Paulo Stanga; In-vivo Imaging and Measurement of the Bursa Premacularis using 1,050nm Swept-Source Deep Range Imaging Optical Coherence Tomography (DRI-OCT1 Atlantis®). Invest. Ophthalmol. Vis. Sci. 2013;54(15):5821.
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© ARVO (1962-2015); The Authors (2016-present)
To image in-vivo the posterior cortical vitreous, the Bursa Premacularis (BPM) and Space of Martegiani and to measure the BPM using a new 1,050nm Swept-Source optical coherence tomography (OCT) scanner (Topcon® Deep Range Imaging, DRI-OCT1 Atlantis®). To determine the relationship between the prevalence and dimensions of the BPM and patient age.
Pilot and retrospective study. One hundred and seventeen consecutive patients (234 eyes, including normal eyes and eyes with various retinal pathologies) underwent DRI-OCT1 Atlantis® scans. Patient age ranged from 5-90 years (mean: 52.4 years). Single-Line 12mm long horizontal scans passing through the fovea and optic disc were assessed. The BPM was measured manually using the system’s software caliper function. The horizontal (width) and the anteroposterior (depth) dimensions of the BPM, as well as the distance between the anterior wall of the BPM and the deepest foveal point, were recorded. Presence of the SM was also recorded.
The BPM and the SM were detected in the posterior cortical vitreous of 54 patients (84 of 234 eyes, 35.9%). All eyes (100%) with a BPM also showed a SM; no eyes (0%) with SM showed absence of BPM. Twenty-four of the 54 patients (44%) showed a unilateral BPM and thirty (56%) showed a bilateral BPM. Bilateral BPM tended to be symmetrical in width but less so in depth (Correlation coefficient: width 0.66 p<0.005; depth 0.45 p=0.013). The BPM was detected more frequently over the age of 20 and up to the age of 76 years. The mean age of patients showing a BPM was 43 years (range: 5 - 76 years). The mean width of the BPM was 7,714 microns (range: 11,312 - 4,339 microns, SD: 1,431) and the mean depth was 501 microns (range: 1,340- 73 microns, SD: 272). Variation in width and depth of the BPM did not correlate with age (Correlation coefficient: width 0.09, p=0.44; depth 0.076, p=0.49).
The utilisation of Swept-Source OCT with 1,050nm wavelength, 100,000 A-line scans/sec and 12mm long scans allows for improved in-vivo anatomical characterisation of the BPM and, for the first time, demonstration of a positive correlation between the presence of BPM and SM. This could be the cohort of patients with the widest range of patient age in whom the cortical vitreous has been assessed in-vivo.
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