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Seong-Woo Kim, Jaeryung Oh, Sang-Kyoon Kim, Jong-Hyun Oh, Cheolmin Yun, Kuhl Huh; Efficacy of NIR and SW-FAF in resolved central serous chorioretinopathy: Detecting outer retinal layer abnormality. Invest. Ophthalmol. Vis. Sci. 2013;54(15):5828.
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To evaluate the correlation of short wave length fundus autofluorescence (SW-FAF) and near-infrared FAF (NIR-FAF) changes with spectral domain-optical coherence tomography (SD-OCT), and FA changes in resolved central serous chorioretinopathy (CSC).
Design is retrospective, observational case study. Patients with a history of resolved CSC and abnormal FAFs imaging were assessed by means of SD-OCT and FA. The outer retinal layer alteration in the OCT image and abnormality in FA were analyzed and correlated with corresponding FAF.
Ninety-one eyes from 86 patients were analyzed. All of abnormal NIR-FAF showed hyper-fluorescent FA window defect in corresponding area. There was a significant association between OCT findings and the SW-FAF findings. Presence of the abnormal SW-FAF was significantly associated with the loss of the photoreceptor inner and outer segment junction (IS/OS) on SD-OCT. (chi-square test; P < 0.0001) NIR-FAF could not predict the status of IS/OS without the SW-FAF image.
Outer retinal layer change in OCT image could be expected by combining both SW-FAF and NIR FAF images together. When abnormal changes were manifested in SW-FAF image, IS/OS damage could be predicted.
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