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Safa Rahmani, Amani Fawzi, Alice Lyon, Irene Maumenee, Marilyn Mets; Ultra-widefield retinal imaging documentation and analysis of peripheral retinal disease in Marfan syndrome: From the Marfan Eye Consortium of Chicago. Invest. Ophthalmol. Vis. Sci. 2013;54(15):5845.
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© ARVO (1962-2015); The Authors (2016-present)
Patients with Marfan syndrome are at high risk of significant retinal pathology including retinal detachments. Examination of these patients is often difficult due to poorly dilating pupils, subluxated lens and young age. This study aimed to report the prevalence of peripheral retinal disease, using the Optos 200Tx imaging device, in a group of Marfan patients.
72 patients were seen on August 2nd as a part of 2012 Marfan Eye Consortium of Chicago. Of the 61 consented patients, posterior color ultra-widefield retinal images were obtained using the Optos 200Tx (age range of tested patients 3-56yrs) on 54 patients (108 eyes). The ability to view the fundus was divided into 2 groups for analysis. Post-equator category: Eyes in which we were able to view posterior pole up to equator) and anterior to equator: eyes where the examiner had sufficient retina view anterior to equator of the peripheral retina. The ultra-widefield color images were analyzed by vitreo-retinal sub-specialist, masked to the clinical exam. Each eye had several images captured, and all images for each eye were used to evaluate the categories. The color composite images were analyzed by separating the red (633 nm) and green channels (532 nm), in the Optos imaging review software, V2 Vantage.
Analysis of the eyes using peripheral ultra-widefield images demonstrated the following findings: pre equatorial retina view in 95% of eyes , pre and post equatorial retina view in 57% of eyes. Retinal pathology (e.g.: peripheral scars, white without pressure) was evident in 24% of eyes analyzed using color, red, and green channels of V2 Vantage. Subluxated lens was evident in 25% of the eyes. The youngest patient photographed was 3 years old at time of study. Young patients (3-12yrs) tolerated the imaging well.
The peripheral retinal anatomy in the Marfan Eye Consortium of Chicago was documented and analyzed using Optos 200Tx. The ultra-widefield imaging documentation by Optos 200Tx ultra-widefield retinal images can be used to assist in fundus examination of Marfan patients that are difficult to evaluate due to their young age, inadequate dilation of pupil or lens subluxation.
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