June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
Retinal vascular abnormalities in the far periphery of pathologic myopic eyes imaged by ultra wide-field fluorescein angiography
Author Affiliations & Notes
  • Yuichiro Kaneko
    Ophthalmology & Visual Science, Tokyo Medical and Dental University Graduate School of Medicine and Dental Sciences, Bunkyo-ku, Japan
  • Muka Moriyama
    Ophthalmology & Visual Science, Tokyo Medical and Dental University Graduate School of Medicine and Dental Sciences, Bunkyo-ku, Japan
  • Noriaki Shimada
    Ophthalmology & Visual Science, Tokyo Medical and Dental University Graduate School of Medicine and Dental Sciences, Bunkyo-ku, Japan
  • Natsuko Nagaoka
    Ophthalmology & Visual Science, Tokyo Medical and Dental University Graduate School of Medicine and Dental Sciences, Bunkyo-ku, Japan
  • Kosei Shinohara
    Ophthalmology & Visual Science, Tokyo Medical and Dental University Graduate School of Medicine and Dental Sciences, Bunkyo-ku, Japan
  • Yuichiro Tanaka
    Ophthalmology & Visual Science, Tokyo Medical and Dental University Graduate School of Medicine and Dental Sciences, Bunkyo-ku, Japan
  • Kyoko Ohno-Matsui
    Ophthalmology & Visual Science, Tokyo Medical and Dental University Graduate School of Medicine and Dental Sciences, Bunkyo-ku, Japan
  • Takashi Tokoro
    Ophthalmology & Visual Science, Tokyo Medical and Dental University Graduate School of Medicine and Dental Sciences, Bunkyo-ku, Japan
  • Shuichiro Hirahara
    Ophthalmology & Visual Science, Nagoya City University Graduate School of Medical Scinences, Nagoya, Japan
  • Yuichiro Ogura
    Ophthalmology & Visual Science, Nagoya City University Graduate School of Medical Scinences, Nagoya, Japan
  • Footnotes
    Commercial Relationships Yuichiro Kaneko, None; Muka Moriyama, None; Noriaki Shimada, None; Natsuko Nagaoka, None; Kosei Shinohara, None; Yuichiro Tanaka, None; Kyoko Ohno-Matsui, None; Takashi Tokoro, None; Shuichiro Hirahara, None; Yuichiro Ogura, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 5848. doi:
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      Yuichiro Kaneko, Muka Moriyama, Noriaki Shimada, Natsuko Nagaoka, Kosei Shinohara, Yuichiro Tanaka, Kyoko Ohno-Matsui, Takashi Tokoro, Shuichiro Hirahara, Yuichiro Ogura; Retinal vascular abnormalities in the far periphery of pathologic myopic eyes imaged by ultra wide-field fluorescein angiography. Invest. Ophthalmol. Vis. Sci. 2013;54(15):5848.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract 
 
Purpose
 

We have previously found that the retinal vasculature in the posterior fundus showed various abnormalities due to mechanical stretching, and have called this condition as myopic retinal vasculopathy. Recently, the imaging of far-peripheral retina is possible by using Optos 200Tx. In the present study, we examined the retinal vasculature in far periphery by using Optos in a large number of highly myopic eyes.

 
Methods
 

One hundred and forty-eight eyes (79 patients) with bilateral high myopia (myopic refractive error ≥-8.00 diopters (D) or axial length >26.5 mm) were studied. For the control, 42 emmetropic eyes which were the fellow eyes of aged-related macular degeneration or central serous chorioretinopathy were examined. The patients who had systemic conditions, such as diabetes of hypertension were excluded. Venous phase of the fluorescein angiographic images taken by Optos 200Tx were analyzed. To exclude the influence of eyelid, we evaluated the nasal and temporal peripheral retina.

 
Results
 

Highly myopic eyes showed various abnormalities in retinal vasculature in the far periphery by Optos. Retinal capillary teleangiectasia was seen in 86.1%, the microaneurysms were seen in 55.4%, the dye leakage from microaneurysms or retinal capillaries was seen in 30.4%, and the avascular area was seen in 83.8%. Teleangiectasia and the microaneurysms were also seen in far-peripheral retina in emmetropic eyes (80.0%, 35.6%). However, the avascular area or the dye leakage was never seen in emmetropic eyes. Even in highly myopic eyes, the avascular area was seen significantly more frequently in eyes whose axial length were > 30 mm than the eyes whose axial length was ≤ 30mm (P < 0.05).

 
Conclusions
 

Various retinal vascular abnormalities are observed in the far periphery by using Optos. These changes were more severe and exaggerated in eyes with pathologic myopia compared to emmetropic eyes, and retinal avascular area was seen only in highly myopic eyes. Mechanical expansion of the equator of the eye might be a cause for retinal vascular alterations in eyes with pathologic myopia.

 
Keywords: 688 retina • 605 myopia • 552 imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound)  
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