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Pimkwan Jaru-ampornpan, Amir Azari, Mozhgan Rezaei Kanavi, Heather Potter, Daniel Albert; Prognostic Factors Associated with Histopathology in Intraocular and Ocular Adnexal Lymphoma: A Twenty Years Review for the University of Wisconsin Madison. Invest. Ophthalmol. Vis. Sci. 2013;54(15):5877.
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To investigate the prognostic factors in ocular and ocular adnexal lymphomas that correlates with histological findings.
After obtaining approval from institutional review board (IRB) committee, a retrospective review of clinical and histologic findings for patients with diagnosis of ocular and/or ocular adnexal lymphoma was conducted at the University of Wisconsin School of Medicine and Public Health between 1992 and 2012. Data examined included patient’s age, gender, presenting signs and symptoms, tumor location, tumor laterality, clinical diagnosis, histological diagnosis and length of survival.
Pertinent clinical and histopathological data was collected on 67 eyes of 60 patients. The average age at diagnosis was 64 ± 16 years (range 14 - 94 years) with a female: male ratio of 1.2. Overall, the total five-year mortality for the ocular lymphomas regardless of location or histological diagnosis was 36% in our study. In regards to tumor location, the intraocular lymphomas carried the worst prognosis with a five-year mortality rate of 100 % in our series (N=8), while the orbital lymphomas carried the best prognosis with a mortality rate of 12% (N=17). In our case series patients with histological diagnosis of large cell lymphoma had a five-year mortality rate of 83% while those with small cell lymphoma (mortality rate of 25%), follicular lymphoma (0% mortality), and mucosa-associated-lymphoid-tissue (MALT) lymphoma (0% mortality) carried a far better prognosis.
After reviewing the experience of a single institution serving a large geographic region of the Midwest, we discovered that the location and the type of lymphoma were similar to those previously reported in the literatures. Patient's prognosis and mortality were influenced by tumor location and tumor histology. In addition, there has not been any significant change in patient’s survival in the recent years with current treatment regimens.
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