June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
Clinical and epidemiologyc features of lymphoproliferative lesions in the orbital and adnexal region at the Asociación Para Evitar la Ceguera en México
Author Affiliations & Notes
  • Linda Guakil
    ORBIT AND OCULOPLASTICS, ASOCIACION PARA EVITAR LA CEGUERA EN MEXICO, MEXICO, Mexico
  • Guillermo Salcedo
    ORBIT AND OCULOPLASTICS, ASOCIACION PARA EVITAR LA CEGUERA EN MEXICO, MEXICO, Mexico
  • Abelardo Rodríguez-Reyes
    PATHOLOGY, ASOCIACION PARA EVITAR LA CEGUERA EN MEXICO, MEXICO, Mexico
  • Rosa Isela Rubio
    ORBIT AND OCULOPLASTICS, ASOCIACION PARA EVITAR LA CEGUERA EN MEXICO, MEXICO, Mexico
  • Footnotes
    Commercial Relationships Linda Guakil, None; Guillermo Salcedo, None; Abelardo Rodríguez-Reyes, None; Rosa Isela Rubio, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 5879. doi:
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      Linda Guakil, Guillermo Salcedo, Abelardo Rodríguez-Reyes, Rosa Isela Rubio; Clinical and epidemiologyc features of lymphoproliferative lesions in the orbital and adnexal region at the Asociación Para Evitar la Ceguera en México. Invest. Ophthalmol. Vis. Sci. 2013;54(15):5879.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: Lymphatic neoplasms are tumours derived from lymphatic ganglia or extraganglionar tissues that arise from lymphocytes and its precursor cells expressing B or T phenotype. Lymphomas are classified as Hodgkin and non- Hodgkin and then subdivided. Ocular adnexal lymphomas develop as primary or secondary tumours in the conjunctiva, lid, orbit, lacrimal gland, or lacrimal sac. Most patients presents with localized disease. Being an ophthalmology reference center, it is important to know the epidemiology of this disease, so the purpose of this study is to evaluate lymphoproliferative lesions of the orbital and adnexal region diagnosed at Asociación Para Evitar La Ceguera en México in a period of 10 years, describe its epidemiology and relationship with the literature, characterize its clinicopathological features and to present clinical cases to exemplify it.

Methods: Patients diagnosed with lymphoproliferative lesions in the ocular adnexa in the years 2002 to 2012 were included. We made a retrospective, observational, descriptive analysis, using the SPSS statistical Package

Results: 74 cases were identified. 45 Female and 29 Male patients with median age of 60 years. Most common presenting symptoms were increase of volume (64.38%) and proptosis (10.96 %). Only 27.12 % presented pain. Pathologic and immunohistochemistry diagnosis coincided in 96.3% of cases. All specimens represented B cell non-Hodgkin’s lymphomas: extranodal marginal zone lymphoma (EMZL) and MALT (n=39), diffuse large B cell lymphoma (n=10), mantle cell lymphoma (n=5), follicle centre lymphoma (n=4), others (n=5). Lymphoid hyperplasia in 11 cases. The orbit (49.32 %) and conjunctiva (35.62%) were the most commonly affected sites. Bilateral involvement in 16.44% of cases. The mayority of patients (76.47%) were sent to a cancerology institute for follow up. The main form of treatment was radiotherapy.

Conclusions: In our experience lymphoproliferative lesions in the orbital and adnexal region are most commonly found in elderly women coinciding with the literature. Orbit and conjunctiva are the most frequently involved sites, this shows some variation in the literature, weret the most common sites are the orbit and eyelid. We found a mayority of low grade b cel lymphoma wich also corresponds with the literature. We found an increase of incidence over time.

Keywords: 744 tumors  
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