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Uma Damle, Sung Chul Park, Rafael Furlanetto, Nora Siegal, Christopher Teng, Jeffrey Liebmann, Robert Ritch; Lamina Cribrosa Position and Age. Invest. Ophthalmol. Vis. Sci. 2013;54(15):59.
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To assess age-dependent changes in the lamina cribrosa (LC) position within the optic nerve head in normal eyes.
Serial horizontal enhanced depth imaging optical coherence tomography (EDI OCT) B-scans of the optic nerve head were obtained from one eye of normal subjects. Interval between EDI OCT B-scans was ~30 μm. After delineating the anterior LC surface, mean and maximum LC depths (reference plane, Bruch’s membrane edges) were measured in 11 equally spaced horizontal B-scans, excluding the LC insertion area under Bruch’s membrane and the scleral rim (Fig A and B). Using the horizontal midline EDI OCT B-scan, the lateral LC displacement from the Bruch’s membrane opening was measured as an angle (θ; Fig C). Mean and maximum LC depths were compared between three age groups (20-39, 40-59, and 60-79 years).
The 86 normal subjects (mean age, 44±18 years) included 44 subjects aged 20-39, 21 aged 40-59, and 21 aged 60-79 years. Both mean and maximum LC depths were similar between the three age groups in all 11 scans, before (all p>0.51; Fig D) and after (all p>0.55) controlling for the angle of lateral LC displacement (θ) and intraocular pressure. The average value of all 11 mean LC depths was 360±72 (range, 239 to 530) µm, 369±76 (range, 274 to 524) µm, and 354±72 (range, 237 to 499) µm in the 20-39, 40-59, and 60-79 years, respectively (p=0.78). The mean and maximum LC depths did not correlate with age either before (all p>0.43; Fig E) or after (all p>0.54) controlling for the angle of lateral LC displacement (θ) and intraocular pressure.
The central and mid-peripheral LC position within the optic nerve head does not change significantly with age under normal conditions. Changes in the LC position appear to be associated with pathologic processes.
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