June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
Short-term Spectral Domain Optical Coherence Tomography Changes after Phacoemulsification in Eyes with No Pre-operative Macular Pathology
Author Affiliations & Notes
  • Yulia Wolfson
    Ophthalmology, Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD
  • Walter Stark
    Ophthalmology, Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD
  • Susan Bressler
    Ophthalmology, Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD
  • Neil Bressler
    Ophthalmology, Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD
  • Footnotes
    Commercial Relationships Yulia Wolfson, None; Walter Stark, VueCare (C); Susan Bressler, Novartis (F), Bausch and Lomb (F), Genentech (F), Thrombogenics (F), Lumenis (F), Notal vision (F), GlaxoSmithKline (C), allergan (F); Neil Bressler, Abbott Medical Optics, inc (F), Alimera Sciences (F), Allergan (F), Bausch &Lomb, Inc (F), Bayer (F), Carl Zeiss Meditec, Inc (F), ForSight Labs, LLC (F), Genentech, Inc (F), Genzyme Corporation (F), Lumenis, Inc (F), Notal VIsion (F), Novartis Pharma AG (F), Pfizer, Inc (F), Regeneron Pharmaceuticals, Inc (F), Roche (F), Thrombogencis (F)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 5924. doi:https://doi.org/
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      Yulia Wolfson, Walter Stark, Susan Bressler, Neil Bressler; Short-term Spectral Domain Optical Coherence Tomography Changes after Phacoemulsification in Eyes with No Pre-operative Macular Pathology. Invest. Ophthalmol. Vis. Sci. 2013;54(15):5924. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: To evaluate short-term changes in macular retinal thickness following cataract surgery in eyes with no pre-operative macular pathology clinically across 3 different spectral domain optical coherence tomography (SD-OCT) devices.

Methods: With IRB approval, a consecutive, convenient cohort of patients scheduled for cataract surgery (89 patients, 101 eyes) with no clinical macular pathology were enrolled prospectively. Predisposing conditions for the post-surgical macular edema, such as diabetes or uveitis, were not exclusion criteria if the pre-op clinical exam of the macula was normal. SD-OCT macular scans on Optovue and either Cirrus or Spectralis SD-OCT devices were performed approximately 15 days pre- and 1-2 months post-op.

Results: Among 92 eyes completing the study, mean central subfield thickness (CST) increased 11, 13 and 9 microns, respectively, from the pre- to post-op visit for Optovue, Cirrus, and Spectralis OCTs, respectively. 6 eyes (7.7%), 4 eyes (10.2%), and 2 eyes (4.5%) experienced at least a 10% increase in the CST using Optovue, Cirrus, and Spectralis scans, respectively. A 3% or greater increase in macular volume was observed in 36%, 51%, and 47% of eyes evaluated by Optovue, Cirrus, and Spectralis OCTs, respectively. One case of post-surgical clinical CME, as diagnosed by the cataract surgeon, was identified among the 92 eyes at day 40.

Conclusions: In the short-term following cataract surgery in eyes with no pre-operative macular pathology, mild macular retinal thickening can be expected, as demonstrated in this study by 3 different SD-OCT devices. Although central retinal thickening is not likely to be clinically relevant in most cases, the integrated change in thickness across all 9 ETDRS subfields, expressed as an increase in the macular volume, can be expected in about half of the eyes. These findings extend previous results using time-domain OCT and provide data which can be considered when evaluating short-term changes in eyes with pre-operative pathology, such as diabetic macular edema, as the findings in this study likely represent the expected distribution of short-term change in retinal thickness and volume following cataract surgery in a population of eyes without pre-operative macular pathology.

Keywords: 585 macula/fovea • 550 imaging/image analysis: clinical • 743 treatment outcomes of cataract surgery  
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