June 2013
Volume 54, Issue 15
ARVO Annual Meeting Abstract  |   June 2013
Change of Tear Secretion in the Lacrimal Glands of High-Fat Diet-Fed C57BL/6J Mice
Author Affiliations & Notes
  • Takaaki Inaba
    keio university, Tokyo, Japan
  • Motoko Kawashima
    keio university, Tokyo, Japan
  • Akiko Ito
    keio university, Tokyo, Japan
  • Mitsuhiro Watanabe
    keio university, Tokyo, Japan
  • Ken Shinmura
    keio university, Tokyo, Japan
  • Tetsuya Kawakita
    keio university, Tokyo, Japan
  • Kazuo Tsubota
    keio university, Tokyo, Japan
  • Footnotes
    Commercial Relationships Takaaki Inaba, None; Motoko Kawashima, Santen Pharmaceutical Co., Ltd (F); Akiko Ito, None; Mitsuhiro Watanabe, None; Ken Shinmura, None; Tetsuya Kawakita, None; Kazuo Tsubota, AcuFocus, Inc (C), Allergan (F), Bausch Lomb Surgical (C), Functional visual acuity meter (P), JiNS (P), Kissei (F), Kowa (F), Santen, Inc. (F), Otsuka (F), Pfizer (C), Thea (C), Echo Denki (P), Nidek (F), Ophtecs (F), Wakasa Seikatsu (F), CEPT Company (P)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 6001. doi:
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      Takaaki Inaba, Motoko Kawashima, Akiko Ito, Mitsuhiro Watanabe, Ken Shinmura, Tetsuya Kawakita, Kazuo Tsubota; Change of Tear Secretion in the Lacrimal Glands of High-Fat Diet-Fed C57BL/6J Mice. Invest. Ophthalmol. Vis. Sci. 2013;54(15):6001.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: Aging is one of the most important factors for the pathogenesis of dry eye disease. Metabolic syndrome accelerates aging. Although several studies have reported that diabetic patients have an elevated incidence of dry eye disease, the mechanism responsible for dry eyes disease remains unclear.

Methods: We investigated the secretion and metabolic changes occurring at 6 months in response to a high-fat diet (HFD).

Results: Tear secretion was decreased by the HFD compared to normal diet at 6 months. Additionally, inflammatory cell infiltration increased in the lacrimal glands of the HFD-fed mice.We also investigated the molecular mechanisms involved including metabolism and aging genes.

Conclusions: The results indicate that aging accelerated by the HFD is related to dry eye.

Keywords: 576 lacrimal gland • 413 aging  

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