June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
Topical atorvastatin for the treatment of dry eye associated with blepharitis
Stephanie Watson; Kenneth Ooi; Frank Billson; Denis Wakefield
Author Affiliations & Notes
  • Stephanie Watson
    Ophthalmology, Save Sight Institute, University of Sydney, Sydney, NSW, NSW, Australia
  • Kenneth Ooi
    Ophthalmology, Save Sight Institute, University of Sydney, Sydney, NSW, NSW, Australia
    Department of Ophthalmology, Prince of Wales Hospital, Sydney, NSW, NSW, Australia
  • Frank Billson
    Ophthalmology, Save Sight Institute, University of Sydney, Sydney, NSW, NSW, Australia
  • Denis Wakefield
    Department of Pathology, School of Medical Sciences, University of New South Wales, Sydney, NSW, NSW, Australia
  • Footnotes
    Commercial Relationships Stephanie Watson, Sydnovate (P); Kenneth Ooi, Sydnovate (P), New South Innovations (P); Frank Billson, None; Denis Wakefield, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 6004. doi:
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      Stephanie Watson, Kenneth Ooi, Frank Billson, Denis Wakefield; Topical atorvastatin for the treatment of dry eye associated with blepharitis. Invest. Ophthalmol. Vis. Sci. 2013;54(15):6004.

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Abstract

Purpose: To investigate topical Atorvostatin, a novel ocular therapy, for the treatment of patients with dry eye associated with blepharitis.

Methods: 10 patients with symptoms and signs of dry eye and blepharitis were enrolled in a prospective pilot study of topical Atorvostatin therapy over 1 month. The primary outcome measure was corneal fluorescein staining.

Results: An improvement in corneal fluorescein staining in the treated eye by more than one point from baseline to completion of the trial at week four was found in 9 of 10 patients (p = 0.007). Topical statin significantly improved the blepharitis score (p = 0.011) and the tear film break-up time (p = 0.005). Subjective dry eye symptoms improved (p = 0.005). There were no serious or irreversible side-effects.

Conclusions: Topical statins are a potential therapy for patients with dry eye and blepharitis. They can be easily manufactured and could be widely available. It may also be of benefit in other dry eye syndromes.

Keywords: 486 cornea: tears/tear film/dry eye • 466 clinical (human) or epidemiologic studies: treatment/prevention assessment/controlled clinical trials • 583 lipids  
© 2013, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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