June 2013
Volume 54, Issue 15
ARVO Annual Meeting Abstract  |   June 2013
Parietal morphometry of retinal arterioles in health and hypertension using adaptive optics
Author Affiliations & Notes
  • Edouard Koch
    Clinial Investigation Center, Quinze-Vingts Hospital-INSERM, Paris, France
    Ophthalmology, Versailles Hospital, Versailles, France
  • David Rosenbaumm
    Cardiology, Pitié Salpétrière Hospital, Paris, France
  • Xavier Girerd
    Cardiology, Pitié Salpétrière Hospital, Paris, France
  • Florence Rossant
    Institut Supérieur d'Electronique de Paris, ISEP, Paris, France
  • Michel Paques
    Clinial Investigation Center, Quinze-Vingts Hospital-INSERM, Paris, France
  • Footnotes
    Commercial Relationships Edouard Koch, None; David Rosenbaumm, None; Xavier Girerd, None; Florence Rossant, None; Michel Paques, MerckSerono (C), Roche (C), Sanofi (C)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 6058. doi:
  • Views
  • Share
  • Tools
    • Alerts
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Edouard Koch, David Rosenbaumm, Xavier Girerd, Florence Rossant, Michel Paques; Parietal morphometry of retinal arterioles in health and hypertension using adaptive optics. Invest. Ophthalmol. Vis. Sci. 2013;54(15):6058.

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

  • Supplements

Purpose: Morphological changes affecting the wall of small retinal arteries are recognized surrogates of end-organ damage secondary to aging and/or arterial hypertension. However, direct observation of the microvascular wall is not feasible with routine imaging techniques. We report here the quantitative analysis of the structure of retinal arterioles (~ 50-150 µm diameter) using adaptive optics (AO) near infrared (NIR) imaging (rtx1 camera; ImagineEyes, France) in normo and hypertensive humans.

Methods: From OA images, the wall-to-lumen ratio (WLR) was calculated using a dedicated software. We compared the WLR between a control group (n = 20; 30.2 ± 6 years) and a group of hypertensive subjects (n = 30, 48.1 ± 13 years). Focal lesions (arteriolar narrowing and arteriovenous nickings) were also analyzed. These data were compared to the carotid intima-media thickness (IMT).

Results: The WLR was significantly higher in the hypertensive group than in controls (0.35 ± 0.071 vs 0.26 ± 0.035, respectively; p=0.017) after correcting for age. The WLR of retinal arterioles was also positively correlated to current arterial pressure (r=0.36; p=0.03) and to IMT (p=0.028). Arteriolar narrowing, but not arteriovenous nickings, showed locally increased WLR. Follow-up of patients under hypotensive treatment (n=7; mean follow-up 6 months) could document progressive vasodilation in two.

Conclusions: Past history of arterial hypertension and current arterial pressure are both associated with increased WLR. Arteriovenous narrowing and arteriovenous nicking show distinct parietal abnormalities and hence are probably due to distinct pathological processes. Thickening of large and small arteries are correlated, suggesting some degree of parallelism of the evolution of macro and microcirculatory damage. We conclude that AO imaging enables to phenotype the microcirculation with an unprecedented precision and may improve the understanding and the management of arterial hypertension.

Keywords: 550 imaging/image analysis: clinical • 688 retina • 549 image processing  

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.