June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
Primary Rescue Therapy In The Treatment Of Threshold Retinopathy Of Prematurity
Author Affiliations & Notes
  • Carlos Abdala
    Retina & Vitreous, Unidad Laser Clinica Oftalmologica, Barranquilla, Colombia
    Ophthalmology, Universidad del Norte, Barranquilla, Colombia
  • Jenny Lobo Lopez
    Retina & Vitreous, Unidad Laser Clinica Oftalmologica, Barranquilla, Colombia
    Ophthalmology, Universidad del Norte, Barranquilla, Colombia
  • Sarah Jordan
    Pediatric Ophthalmology, Cole Eye Institute, Cleveland Clinic, Cleveland, OH
  • Paul Rychwalski
    Pediatric Ophthalmology, Cole Eye Institute, Cleveland Clinic, Cleveland, OH
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 610. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Carlos Abdala, Jenny Lobo Lopez, Sarah Jordan, Paul Rychwalski; Primary Rescue Therapy In The Treatment Of Threshold Retinopathy Of Prematurity. Invest. Ophthalmol. Vis. Sci. 2013;54(15):610.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose: Describe the clinical characteristics and outcomes of children with Retinopathy of Prematurity (ROP) who were screened and treated in 11 Neonatal Intensive Care Units in Colombia between January 2008 - June 2012.

Methods: 749 eyes were examined in 377 infants born with a gestational age (GA) of 32 weeks or less and a birth weight (BW) of 1750 g or less. One observer screened all infants at the fifth week of life or by 34 weeks post- conception.

Results: 152 of 377 patients (40%) had any type of ROP, affecting 299 eyes. 181 eyes of 97 patients required surgery (24%). 127 eyes of 69 patients required Laser Photocoagulation and 54 eyes of 28 patients required Primary Rescue Therapy (Laser and intravitreal injection of anti-VEGF). 34 eyes of 18 patients in the laser group were lost to follow-up and 4 eyes of 2 infants in the Primary Rescue Therapy group were similarly lost to follow-up. In addition, 4 eyes of 3 patients of this last group were excluded due to progression to Stage 4 ROP before treatment. In this report we analyze the results of the Primary Rescue Therapy Group. 46 eyes of 23 patients had a mean GA of 27,6 weeks. More than 50% of infants were born between 27 and 29 weeks. 100% of the patients with ROP were born < 32 weeks of gestation. The mean BW was 1008,4 g. 87% of the infants of this group weighed 1500 g or less at birth. 6/23 (26%) had a BW of between 1001 and 1500 g and 14/23 (61%) had a BW of 1000 g or less. All infants of this group had Threshold ROP. Eight eyes (17,39%) required a second rescue therapy treatment (fifteen days after the initial therapy) in order to obtain regression of ROP.

Conclusions: The development of ROP is related to low birth weight and gestational age. In our series, the infants had a mean BW of 1008 g with 87% of infants having a BW of 1500 g or less. 61% had a BW of 1000 g or less. In our group of patients, this was a significant risk factor in the development of threshold ROP. The combination of Laser and Anti-VEGF proved to be effective in treating Threshold ROP and halting the progression of the ROP in 93.5% of infants. Finally, 8/46 eyes (17.3%) required a second treatment in order to obtain the complete regression of the disease.

Keywords: 706 retinopathy of prematurity  
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×