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Yoshiaki Shimada, Akira Nakamura, Atsuhiro Tanikawa, Masayuki Horiguchi; Slow flash multifocal electroretinograms in the foveola. Invest. Ophthalmol. Vis. Sci. 2013;54(15):6136.
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© ARVO (1962-2015); The Authors (2016-present)
To investigate the characteristics of multifocal electroretinogram (mfERG) in the foveola.
mfERGs were recorded from 5 healthy trained subjects with isomeric 509 stimulus elements, 18.75 Hz base-rate, 29 minutes net recording time and 2.67 cds/m2 stimulus intensity. The response at the centermost element corresponding to the foveola (≤1.0 degree in diameter) was assessed as the foveolar mfERG.
The first order kernel (K1) of the foveolar mfERG had the prolonged peak times of the b-wave and the negative deflection following the b-wave, while the a-wave peak time was not extended. The first slice of the second order kernel (K2.1) of the foveolar mfERG was strikingly larger than that of the surrounding mfERGs and unique in shape with the prominent component with a long peak time around 50 ms (P50) .
The 2.1 waveform in the foveola was different from that of the surrounding mfERGs or that obtained by full field pseudorandom stimuli (Hori et al. 2003). Although the K2.1 waveform varies deeply depending on the base rate, the P50 had dominated the K2.1 of the foveolar mfERG even with the fast (75 Hz base-rate) flash (Shimada et al. 2012). The wider temporal divergence between the a-wave and the following components in the K1, and P50 in the K2.1 of the foveolar mfERG probably reflect the peculiar and expansive neural structures in the foveola.
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