Purchase this article with an account.
Noemi Lois, Augusto Azuara-Blanco, Graham Mowatt, Mayret Castillo de Chacon, Andrew Elders, Craig Ramsay, Jennifer Burr; The role of Optical Coherence Tomography (OCT) for the diagnosis, monitoring, and guiding of treatment for neovascular Age-related Macular Degeneration (nAMD): an evidence synthesis study. Invest. Ophthalmol. Vis. Sci. 2013;54(15):6285.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
To determine the optimal role of OCT in diagnosing and monitoring nAMD (detecting disease activity and the need for further anti-VEGF treatment).
Systematic review. Major electronic databases and websites were searched. Studies were included if they reported the diagnostic performance of time domain or spectral domain OCT (or selected other tests) against a reference standard of ophthalmologist-interpreted fluorescein angiography in people with newly suspected or previously diagnosed nAMD. Risk of bias was assessed by two independent investigators using QUADAS-2. Summary receiver operating characteristic (SROC) curves were produced for each test given sufficient data.
3700 titles/abstracts were screened, and 120 (3.2%) were selected for full-text assessment. A total of 22 studies were included (17 on diagnosis, 7 monitoring, and 3 both). From 15 studies reporting OCT data, sensitivity and specificity ranged from 59% to 100% and 27% to 100%, respectively.
The reported diagnostic performance of OCT showed large variability. The methodological quality of most studies was sub-optimal.
This PDF is available to Subscribers Only