June 2013
Volume 54, Issue 15
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ARVO Annual Meeting Abstract  |   June 2013
Enhanced Depth Imaging Optical Coherence Tomography of the Choroid in eyes with Geographic Atrophy secondary to Age-related Macular Degeneration
Athanasios Bezatis; Eva Becker; Christian Brinkmann; Steffen Schmitz-Valckenberg; Rolf Fimmers; Monika Fleckenstein; Frank Holz
Author Affiliations & Notes
  • Athanasios Bezatis
    Ophthalmology, University of Bonn, Bonn, Germany
  • Eva Becker
    Ophthalmology, University of Bonn, Bonn, Germany
  • Christian Brinkmann
    Ophthalmology, University of Bonn, Bonn, Germany
  • Steffen Schmitz-Valckenberg
    Ophthalmology, University of Bonn, Bonn, Germany
  • Rolf Fimmers
    Institute for Medical Biometry, Informatics and Epidemiology, Bonn, Germany
  • Monika Fleckenstein
    Ophthalmology, University of Bonn, Bonn, Germany
  • Frank Holz
    Ophthalmology, University of Bonn, Bonn, Germany
  • Footnotes
    Commercial Relationships Athanasios Bezatis, Heidelberg Engineering,Germany (F), Carl Zeiss Meditec, Germany (F), Optos, UK (F); Eva Becker, Heidelberg Engineering, Germany (F), Carl Zeiss Meditec, Germany (F), Optos, UK (F); Christian Brinkmann, Heidelberg Engineering, Germany (F), Carl Zeiss Meditec, Germany (F), Optos, UK (F); Steffen Schmitz-Valckenberg, Heidelberg Engineering (F), Optos (F), Carl Zeiss Meditec (F), Heidelberg Engineering (R), Genentech (C), Novartis (C), Novartis (R), Roche (R), Novartis (F); Rolf Fimmers, None; Monika Fleckenstein, Heidelberg Engineering, Germany (F), Heidelberg Engineering, Germany (C), Heidelberg Engineering, Germany (R), Carl Zeiss Meditec, Germany (F), Optos, UK (F), Optos, UK (C); Frank Holz, Acucela (C), Allergan (C), Genentech (F), Heidelberg Engineering (F), Zeiss (F), Novartis (F), Novartis (C), Optos (F), Merz (C), Bayer (F), Bayer (C), Boehringer Ingelheim (C)
  • Footnotes
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Investigative Ophthalmology & Visual Science June 2013, Vol.54, 6299. doi:
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      Athanasios Bezatis, Eva Becker, Christian Brinkmann, Steffen Schmitz-Valckenberg, Rolf Fimmers, Monika Fleckenstein, Frank Holz; Enhanced Depth Imaging Optical Coherence Tomography of the Choroid in eyes with Geographic Atrophy secondary to Age-related Macular Degeneration. Invest. Ophthalmol. Vis. Sci. 2013;54(15):6299.

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Abstract
 
Purpose
 

To compare the subfoveal choroidal thickness (SCT) in eyes with geographic atrophy (GA) secondary to age-related macular degeneration (AMD) with normal eyes using enhanced depth imaging optical coherence tomography (EDI-OCT).

 
Methods
 

A total of 42 eyes (42 patients, mean age: 77.4 ± 7.5 years) with GA and 40 eyes of 40 healthy subjects (mean age 74.6 ± 5.9 years) were examined by confocal scanning laser ophthalmoscopy (cSLO) and EDI-OCT (Spectralis HRA+OCT, Heidelberg Engineering, Germany). Two independent readers measured the SCT. Analysis included Bland-Altman statistics and correlation of SCT with age, gender and refractive error (RE, eyes with RE > -3 D have been excluded from the analysis), respectively. In the GA group, SCT was also correlated with both uni-/multifocality and the total size of the atrophic area measured by semi-automated image analysis software (RegionFinder, Heidelberg Engineering).

 
Results
 

Mean SCT was significantly thinner in the GA group (154.2 ± 70.8 µm) compared to the control group (231.9 ± 60.3 µm) (p=0.001). Mean interobserver agreement for SCT measurements was 20.0 µm (95% confidence interval (CI) [-3.3; 1.1]). In both groups, there was a significantly negative correlation between SCT and age (p=0.004) while gender and RE (range -1.75 to +3.36 D) were not significantly correlated with SCT (p=0.95 and p=0.72) respectively. In the GA group, there was no significant correlation between SCT and neither total size of atrophy (mean 8.98 ± 7.48 mm2, p=0.46) nor uni-/multifocality (p=0.98).

 
Conclusions
 

The results indicate that advanced dry AMD is associated with thinner choroid compared to normal eyes. This may possibly implicate alterations in choroidal perfusion and supply to outer retinal layers as a pathophysiologic factor in the development and progression of GA.

 
Keywords: 412 age-related macular degeneration • 452 choroid • 585 macula/fovea  
© 2013, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2024 Association for Research in Vision and Ophthalmology.
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