June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
Role of biomechanical properties of fibrous coat of the eye in intraocular pressure changes in patients after intravitreal ranibizumab injections. Pilot study
Author Affiliations & Notes
  • Ekaterina Chikun
    State Research Institute of Eye Disease of Russian Academy of Medical Sciences, Moscow, Russian Federation
  • Maria Karpilova
    State Research Institute of Eye Disease of Russian Academy of Medical Sciences, Moscow, Russian Federation
  • Aleksey Kuznetsov
    State Research Institute of Eye Disease of Russian Academy of Medical Sciences, Moscow, Russian Federation
  • Irina Andreeva
    State Research Institute of Eye Disease of Russian Academy of Medical Sciences, Moscow, Russian Federation
  • Olga Gabina
    State Research Institute of Eye Disease of Russian Academy of Medical Sciences, Moscow, Russian Federation
  • Anna Plyukhova
    State Research Institute of Eye Disease of Russian Academy of Medical Sciences, Moscow, Russian Federation
  • Maria Budzinskaya
    State Research Institute of Eye Disease of Russian Academy of Medical Sciences, Moscow, Russian Federation
  • Valery Erichev
    State Research Institute of Eye Disease of Russian Academy of Medical Sciences, Moscow, Russian Federation
  • Sergey Avetisov
    State Research Institute of Eye Disease of Russian Academy of Medical Sciences, Moscow, Russian Federation
  • Footnotes
    Commercial Relationships Ekaterina Chikun, Novartis (R); Maria Karpilova, None; Aleksey Kuznetsov, None; Irina Andreeva, None; Olga Gabina, None; Anna Plyukhova, Novartis (R); Maria Budzinskaya, Novartis (F); Valery Erichev, None; Sergey Avetisov, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 6307. doi:https://doi.org/
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      Ekaterina Chikun, Maria Karpilova, Aleksey Kuznetsov, Irina Andreeva, Olga Gabina, Anna Plyukhova, Maria Budzinskaya, Valery Erichev, Sergey Avetisov; Role of biomechanical properties of fibrous coat of the eye in intraocular pressure changes in patients after intravitreal ranibizumab injections. Pilot study. Invest. Ophthalmol. Vis. Sci. 2013;54(15):6307. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: The purpose of the present research was to analyze the influence of biomechanical properties of fibrous coat of the eye on intraocular pressure (IOP) in patients after intravitreal ranibizumab injections.

Methods: The study involved 60 patients (60 eyes) with wet age-related macular degeneration without history of glaucoma or ocular hypertension. 0,05 ml (0,5 mg) of ranibizumab was injected into the vitreous. IOP was measured before and 1 minute after the injection with the Icare ONE tonometer (Finland). Biomechanical properties of the cornea such as corneal hysteresis (CH) and corneal resistance factor (CRF) were examined two weeks after the last injection (after IOP normalization without medication) with an Ocular Response Analyzer (Reichert ORA, USA).

Results: One minute after injection IOP in all patients was elevated by 14,0±0,39 to 36,9±1,5 mm Hg. In 7 patients IOP after injection was more than 35 mm Hg, CH and CRF in these eyes were 7,25±0,33 and 10,2±0,7 respectively. In 5 other patients IOP after injection was less than 15 mm Hg, CH and CRF were 9,88±0,33 and 9,9±0,66 respectively. Difference in CH was statistically significant (p=0,021).

Conclusions: Viscoelastic property of fibrous coat of the eye is characterized by CH. Lower CH determines elevated IOP after intravitreal ranibizumab injection.

Keywords: 412 age-related macular degeneration • 479 cornea: clinical science • 568 intraocular pressure  
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