June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
Index of Non Circularity as a Predictor for Progression in Eyes with Geographic Atrophy (GA)
Author Affiliations & Notes
  • Ronald Danis
    Ophthalmology & Visual Sciences, Univ of Wisconsin-Madison, Madison, WI
  • Amitha Domalpally
    Ophthalmology & Visual Sciences, Univ of Wisconsin-Madison, Madison, WI
  • Ellie Corkery
    Ophthalmology & Visual Sciences, Univ of Wisconsin-Madison, Madison, WI
  • Ruth Shaw
    Ophthalmology & Visual Sciences, Univ of Wisconsin-Madison, Madison, WI
  • Ashwini Narkar
    Ophthalmology & Visual Sciences, Univ of Wisconsin-Madison, Madison, WI
  • James White
    Ophthalmology & Visual Sciences, Univ of Wisconsin-Madison, Madison, WI
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 6311. doi:
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      Ronald Danis, Amitha Domalpally, Ellie Corkery, Ruth Shaw, Ashwini Narkar, James White; Index of Non Circularity as a Predictor for Progression in Eyes with Geographic Atrophy (GA). Invest. Ophthalmol. Vis. Sci. 2013;54(15):6311.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: Given that baseline area and configuration of GA are associated with its progression rate, we hypothesized that a non circular configuration has a higher growth rate. Index of non circularity was developed on color photographs and was a strong predictor of progression rate of GA. The purpose of this study is to evaluate the index in a sample of autofluorescence images submitted for the Age Related Eye Disease Study 2 (AREDS2).

Methods: Among 63 eyes with GA that had incident or baseline GA with 2 years of follow up, the perimeter and area of GA was measured from autofluorescence images (Heidelberg) using planimetry. A Non-Circularity Index (NCI) was calculated based upon the ratio of the measured area of GA (actual area) to the area of GA expected for a given perimeter (expected area) NCI = actual area/expected area; range 0.0 to 1.0; a value of 1.0 indicates a circular shape and departure from 1.0 indicates non circularity or an irregular shape. The relationship between progression rates of GA area by autofluorescence imaging and NCI were analyzed in this pilot sample.

Results: The mean area of GA at baseline was 5.27 mm2 (+/- 0.81 95% CI). Baseline NCI was categorized as 0-0.25 (n=22), 0.26-0.50 (n= 23), 0.51-0.75 (n=13), and 0.76-1.0 (n=5). The mean progression rates of GA for these NCI categories were 2.16, 1.87, 1.25, and 0.93 mm2/yr respectively (p<0.01ANOVA).

Conclusions: In this pilot sample, NCI is moderately associated with progression rate of GA. Using semi automated software for GA segmentation, availability of NCI as an automated output may be helpful prognostic factor and might be considered as a parameter to assist with clinical trial eligibility.

Keywords: 412 age-related macular degeneration • 550 imaging/image analysis: clinical • 462 clinical (human) or epidemiologic studies: outcomes/complications  
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