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Hyemi Jung, Hee-Bae Ahn, Mee sook Roh, Won Yeol Ryu, Yoon Hyung Kwon; The Efficacy of Seprafilm® Graft with Adhesiolysis in Experimentally Induced Lid Adhesion in Rabbits. Invest. Ophthalmol. Vis. Sci. 2013;54(15):6382. doi: https://doi.org/.
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To evaluate the efficacy of subsequent seprafilm® transplantation following adhesiolysis for preventing postoperative readhesion and improving the results of surgery.
Primary blepharoplasty was done on both eyelids of 18 albino rabbits. After 2 weeks, a new skin incision was made and adhesiolysis was done on both eyelids. The rabbits were categorized into two groups, one with adhesiolysis alone in left eyelids (control group), and the other with adhesiolysis with seprafilm® graft in right eyelids (seprafilm® group). The degree of inflammation and fibrosis were examined on Hematoxylin-eosin(H & E), Masson trichrome stain. Expression of α-smooth muscle actin(α-SMA) was immunohistochemically examined.
On eyelid examination directly after the operation, mild swelling and hemorrhage was detected in both groups, but after 1 -2 week, the swelling and hemorrhage was resolved and the shape of the eyelids had recovered completely in both groups. In microscopic findings, the seprafilm® group showed less inflammation and fibrosis than the control group. The seprafilm® group showed less α -SMA positive cell than the conrol group.
From these findings, we suggest that the use of seprafilm® graft after adhesiolysis and blepharoplasty is an effective method for prevention of postoperative readhesion and good result of post blepharoplasty.
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