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Yukitoshi Shimoda, Shoji Kishi; Evaluation of fundus autofluorescence in retinitis pigmentosa using ultra wide-field scanning laser ophthalmoscope. Invest. Ophthalmol. Vis. Sci. 2013;54(15):646.
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We evaluated fundus autofluorescence images in retinitis pigmentosa using ultra wide-field scanning laser ophthalmoscope.
Fundus autofluorescence (FAF), spectral-domain optical coherence tomography (OCT) and full-field electroretinogram (full-field ERG) were prospectively examined in 20 eyes of 10 cases who were clinically diagnosed with a retinitis pigmentosa.
In 8 eyes (40%) of 20 eyes, a ring-like hyper FAF at macula (ring FAF) or a hypo FAF around vascular arcade area were observed. A diffuse hypo FAF at peripheral retina was demonstrated in 4 eyes (20%) and a diffuse hypo FAF at whole retina was showed in 9 eyes (45%). In 8 eyes with the ring FAF, the mean best-corrected visual acuity (BCVA) was good (from 1.0 to 1.2) and photoreceptor inner and an outer segment (IS/OS) lines were remained inside a ring FAF area, while these IS/OS lines were defected at the surrounding area of the ring FAF. In 5 eyes with a diffuse hypo FAF at whole retina and no ring FAF, the mean BCVA was poor (from light sense to 0.06) and these IS/OS lines were defected at macular area. In 2 eyes with both a ring FAF and a diffuse hypo FAF at peripheral retina, and in 9 eyes with a diffuse hypo FAF at whole retina, cone and rod components in full-field ERG were completely disappeared.
Using ultra wide-field scanning laser ophthalmoscope, fundus autofluorescence of wide range could observe in retinitis pigmentosa. The finding of a ring-like hyper FAF indicated remaining of a foveal IS/OS line and good visual acuity. The existence of a diffuse hypo FAF in whole retina was thought to be a serious damage of retinal function.
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