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Roberto Vessani, Vitor Prado, Paula Borba, Paula Silva, Igor Matsubara, Augusto Paranhos, Tiago Prata; Relationship of Optic Disc Cup with Lamina Cribrosa and Prelaminar Tissue in Healthy and Glaucomatous Eyes: In Vivo Quantification with Spectral-Domain Optical Coherence Tomography. Invest. Ophthalmol. Vis. Sci. 2013;54(15):76.
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To investigate the relationship of optic disc cup with lamina cribrosa (LC) thickness and prelaminar tissue thickness in optic nerve head (ONH) using spectral-domain optical coherence tomography (SD-OCT) in healthy and glaucomatous eyes.
Healthy individuals and glaucomatous patients with a wide range of disease stage (glaucomatous optic neuropathy with reproducible visual field defect) were prospectively enrolled. A complete ophthalmological examination was performed and patients with significant media opacity or any other ocular disease were excluded. All participants underwent SD-OCT imaging (Spectralis; Heidelberg Engineering GmbH, Heidelberg, Germany). Subjects were imaged using the EDI technique. The following ONH parameters were measured by an experienced examiner masked to patients clinical data:central LC thickness, prelaminar tissue thickness, Bruch’s membrane opening and central cup depth. Possible associations between these parameters were evaluated.
Twenty-one eyes of 21 patients were included. Multiple regression analysis (controlled by optic disc size) revealed a significant negative association between cup depth and prelaminar tissue thickness (r=-0.63, p=0.01). Cup depth was also significantly correlated with LC thickness (r=-0.48, p=0.02). Eyes with deeper optic disc cup presented thinner LC.
In this study, in vivo assessment of ONH structures in healthy subjects and glaucomatous patients revealed that eyes with deeper ONH cup presented less prelaminar tissue and thinner lamina cribrosa, independent of optic disc size.
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