June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
Retinal ganglion cell dysfunction precedes death in glaucoma suspects
Author Affiliations & Notes
  • Gabriel Luna
    Ophthalmology, Bascom Palmer Eye Institute, Miami, FL
  • Eleonore Savatovsky
    Ophthalmology, Bascom Palmer Eye Institute, Miami, FL
  • Brandon Bosse
    Ophthalmology, Bascom Palmer Eye Institute, Miami, FL
  • Michael Banitt
    Ophthalmology, Bascom Palmer Eye Institute, Miami, FL
  • Olga Shif
    Ophthalmology, Bascom Palmer Eye Institute, Miami, FL
  • Lori Ventura
    Ophthalmology, Bascom Palmer Eye Institute, Miami, FL
  • Vittorio Porciatti
    Ophthalmology, Bascom Palmer Eye Institute, Miami, FL
  • William Feuer
    Ophthalmology, Bascom Palmer Eye Institute, Miami, FL
  • Footnotes
    Commercial Relationships Gabriel Luna, None; Eleonore Savatovsky, None; Brandon Bosse, None; Michael Banitt, None; Olga Shif, None; Lori Ventura, None; Vittorio Porciatti, None; William Feuer, Abbott Medical optics (F), New World Medical (F)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 796. doi:https://doi.org/
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      Gabriel Luna, Eleonore Savatovsky, Brandon Bosse, Michael Banitt, Olga Shif, Lori Ventura, Vittorio Porciatti, William Feuer; Retinal ganglion cell dysfunction precedes death in glaucoma suspects. Invest. Ophthalmol. Vis. Sci. 2013;54(15):796. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: To estimate the timelag between retinal ganglion cell (RGC) dysfunction and death in patients suspected of glaucoma by comparing progressive losses of pattern electroretinogram (PERG) and retinal nerve fiber layer (RNFL) thickness over time.

Methods: Glaucoma suspects (N=107, 201 eyes) were monitored with PERG and optical coherence tomography (OCT) every six months for at least four years. Longitudinal PERG amplitudes and peripapillary retinal nerve fiber layer (RNFL) thicknesses were normalized on their respective dynamic range (difference between the values in normal subjects and advanced stages of the disease) and fitted with linear functions. Individual slopes were pooled. The time lag for PERG and OCT to lose 10% of their baseline value was calculated.

Results: In eyes with abnormal baseline PERG amplitude (50-90% loss from normal average, N=99), pooled PERG amplitude slopes took 1.9 - 2.5 years to lose 10% of their initial amplitude, whereas the RNFL thickness took 9.9 - 10.4 (P<0.05). Thus, the time lag between PERG amplitude and RNFL thickness to lose 10% of their initial values appears to be of the order of 8 years.

Conclusions: In glaucoma suspects, PERG signal anticipates an equivalent loss of OCT signal by several years.

Keywords: 507 electrophysiology: clinical • 531 ganglion cells • 496 detection  
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