June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
Evaluation of Pre-perimetric Glaucoma Patients using Short Duration Transient Visual Evoked Potentials (SD-tVEP)
Author Affiliations & Notes
  • Peter Derr
    Engineering, Diopsys Inc, Pine Brook, NJ
  • Rafael Furlanetto
    Einhorn Clinical Research Center, New York Eye and Ear Infirmary, New York, NY
  • Gustavo De Moraes
    Einhorn Clinical Research Center, New York Eye and Ear Infirmary, New York, NY
    NYU School of Medicine, New York, NY
  • Alberto Gonzalez Garcia
    Engineering, Diopsys Inc, Pine Brook, NJ
  • Celso Tello
    Einhorn Clinical Research Center, New York Eye and Ear Infirmary, New York, NY
  • Jeffrey Liebmann
    Engineering, Diopsys Inc, Pine Brook, NJ
    NYU School of Medicine, New York, NY
  • Robert Ritch
    Engineering, Diopsys Inc, Pine Brook, NJ
    Department of Ophthalmology, New York Medical College, Valhalla, NY
  • Footnotes
    Commercial Relationships Peter Derr, Diopsys Inc (E); Rafael Furlanetto, None; Gustavo De Moraes, None; Alberto Gonzalez Garcia, Diopsys (E); Celso Tello, DIOPSYS (C); Jeffrey Liebmann, Alcon Laboratories, Inc. (C), Allergan, Inc. (C), Allergan, Inc. (F), Carl Zeiss Meditech, Inc (F), Heidelberg Engineering, GmbH (F), Topcon Medical Systems, Inc. (F), National Eye Institute (F), New York Glaucoma Research Institute (F), SOLX, Inc. (C), Bausch & Lomb, Inc (C), Diopsys, Inc. (C), Diopsys, Inc. (F), Merz, Inc. (C), Glaukos, Inc. (C), Quark, Inc. (C); Robert Ritch, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 797. doi:https://doi.org/
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      Peter Derr, Rafael Furlanetto, Gustavo De Moraes, Alberto Gonzalez Garcia, Celso Tello, Jeffrey Liebmann, Robert Ritch; Evaluation of Pre-perimetric Glaucoma Patients using Short Duration Transient Visual Evoked Potentials (SD-tVEP). Invest. Ophthalmol. Vis. Sci. 2013;54(15):797. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: To evaluate the response of the Short Duration Transient Visual Evoked Potentials (SD-tVEP) on patients with pre-perimetric glaucoma (PrG).

Methods: Inclusion criteria were best corrected visual acuity of 20/30 or better normal 24-2 SITA-Standard visual fields (VF) in patients with glaucomatous optic neuropathy. Pre-perimetric glaucoma was defined by the presence of significant retinal nerve fiber layer thinning measured by spectral-domain optical coherence tomography (Spectralis, Heidelberg) whereas normal subjects (control group) had no abnormalities on this test. SD-tVEPs were recorded using the Diopsys NOVA System (Diopsys, Inc. Pine Brook, NJ). Each eye was stimulated with a 15% (Lc) and 85% (Hc) Michelson contrast checkerboard pattern. Test duration was 30 seconds/eye and each test resulted in a low- and high-contrast response. Each response was evaluated for overall waveform quality, P100 latency, and the amplitude difference of the P100 and N75. The two AUC-ROC analysis was performed on the both the Hc and Lc SD-tVEP parameters.

Results: 36 PrG patients and 30 controls with normal eyes were enrolled. There was difference in SD-tVEP Lc latency parameter between cases and controls (P=0.0032). Evaluating the SD-tVEP Lc parameters, the AUCs were 0.72 (0.59-0.86) for P100 latency and 0.58 (0.44-0.72) for P100 amplitude. Evaluating the SD-tVEP Hc parameters, the AUCs were 0.68 (0.55-0.81) for P100 latency and 0.58 (0.44-0.72) for P100 amplitude.

Conclusions: The low contrast SD-tVEP latency parameter produced the greatest AUC. The SD-tVEP low contrast latency parameter was able to differentiate normal and PrG patients and may be useful for the diagnosis of glaucoma with structural abnormalities but normal achromatic perimetry.

Keywords: 507 electrophysiology: clinical • 531 ganglion cells  
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