June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
Inflammatory and Oxidative Stress Markers and the 20-Year Cumulative Incidence of Age-Related Cataract: the Beaver Dam Eye Study
Author Affiliations & Notes
  • Barbara Klein
    Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI
  • Chelsea Myers
    Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI
  • Karen Cruickshanks
    Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI
    Population Health Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI
  • Kristine Lee
    Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI
  • Ronald Klein
    Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI
  • Footnotes
    Commercial Relationships Barbara Klein, None; Chelsea Myers, None; Karen Cruickshanks, None; Kristine Lee, None; Ronald Klein, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 897. doi:https://doi.org/
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      Barbara Klein, Chelsea Myers, Karen Cruickshanks, Kristine Lee, Ronald Klein; Inflammatory and Oxidative Stress Markers and the 20-Year Cumulative Incidence of Age-Related Cataract: the Beaver Dam Eye Study. Invest. Ophthalmol. Vis. Sci. 2013;54(15):897. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: To determine whether inflammatory and oxidative stress markers are associated with the 20-year cumulative incidence of types of age-related cataract.

Methods: A randomized sample (N=1597) of the Beaver Dam Eye Study cohort was identified for assessment of 4 inflammatory markers (serum high sensitivity C-reactive protein [CRP], tumor necrosis factor-α [TNF-α], interleukin-6 [IL-6], and white blood cell [WBC] count) and 2 oxidative stress markers (serum isoprostane and total carbonyl content) at baseline, and were examined at 4 follow-up exams spaced 5 years apart. Age-related cataract was assessed from photographs of the lens.

Results: The 20-year cumulative incidence of any cataract was 54.1% and was 35.3%, 11.7% and 29.9% for nuclear, posterior subcapsular cataract and cortical cataract, respectively. After adjusting for age and sex, TNF-α (results reported as odds ratio for trend per quartile, 95% confidence interval, P value; 1.23, 1.09-1.38, P=0.0005) and IL-6 (1.27, 1.15-1.41, P<0.0001) were associated with the incidence of any cataract. Stratifying by cataract type, IL-6 was significantly associated with the incidence of nuclear cataract (1.15, 1.03-1.29, P=0.016); both IL-6 (1.24, 1.10-1.40, P=0.0004) and WBC count (1.18, 1.05-1.32, P=0.006) were associated with the incidence of cortical cataract; CRP (1.25, 1.05-1.48, P=0.01) was associated with the incidence of posterior subcapsular cataract. Odds ratios and significance levels were nearly identical after further adjustment for other potential confounders.

Conclusions: Our findings provide modest support for an association between markers of inflammation and the incidence of age-related cataract over 20 years. It is possible that more specific information on the cause of systemic inflammation would be useful in understanding these relationships.

Keywords: 445 cataract • 463 clinical (human) or epidemiologic studies: prevalence/incidence • 557 inflammation  
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