June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
The Relationship between Ocular Surface Epithelial Damage and Tear Abnormalities: Osaka Study
Hiroaki Kato; Norihiko Yokoi; Aoi Komuro; Yukiko Sonomura; Yuichi Uchino; Miki Uchino; Dogru Murat; Motoko Kawashima; Kazuo Tsubota; Shigeru Kinoshita
Author Affiliations & Notes
  • Hiroaki Kato
    Department of Ophthalmology, Kyoto Prefectural University of Medcine, Kyoto, Japan
  • Norihiko Yokoi
    Department of Ophthalmology, Kyoto Prefectural University of Medcine, Kyoto, Japan
  • Aoi Komuro
    Department of Ophthalmology, Kyoto Prefectural University of Medcine, Kyoto, Japan
  • Yukiko Sonomura
    Department of Ophthalmology, Kyoto Prefectural University of Medcine, Kyoto, Japan
  • Yuichi Uchino
    Department of Ophthalmology, Keio University School of Medcine, Tokyo, Japan
  • Miki Uchino
    Department of Ophthalmology, Keio University School of Medcine, Tokyo, Japan
  • Dogru Murat
    Department of Ophthalmology, Keio University School of Medcine, Tokyo, Japan
  • Motoko Kawashima
    Department of Ophthalmology, Keio University School of Medcine, Tokyo, Japan
  • Kazuo Tsubota
    Department of Ophthalmology, Keio University School of Medcine, Tokyo, Japan
  • Shigeru Kinoshita
    Department of Ophthalmology, Kyoto Prefectural University of Medcine, Kyoto, Japan
  • Footnotes
    Commercial Relationships Hiroaki Kato, Santen Pharmaceutical (F); Norihiko Yokoi, Santen Pharmaceutical (F), Otsuka Pharmaceutical (F), Kowa (P), Kissei Pharmaceutical (C), Menicon (F), Alcon Japan (F), White medical (F), Nitten (F), Rohto (C), Nidek (F), Johson & Johnson (F); Aoi Komuro, Santen pharmaceutical (F); Yukiko Sonomura, Santen pharmaceutical (F); Yuichi Uchino, Santen Pharmaceutical (F); Miki Uchino, Santen Pharmaceutical Co (F); Dogru Murat, Otsuka Pharmaceuticals (F); Motoko Kawashima, Santen Pharmaceutical Co., Ltd (F); Kazuo Tsubota, AcuFocus, Inc (C), Allergan (F), Bausch Lomb Surgical (C), Functional visual acuity meter (P), JiNS (P), Kissei (F), Kowa (F), Santen, Inc. (F), Otsuka (F), Pfizer (C), Thea (C), Echo Denki (P), Nidek (F), Ophtecs (F), Wakasa Seikatsu (F), CEPT Company (P); Shigeru Kinoshita, Senju Pharmaceutical Co (P), Santen Pharmaceutical Co (P), Otsuka Pharmaceutical Co (C), Alcon (R), AMO (R), HOYA (R)
  • Footnotes
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Investigative Ophthalmology & Visual Science June 2013, Vol.54, 939. doi:
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      Hiroaki Kato, Norihiko Yokoi, Aoi Komuro, Yukiko Sonomura, Yuichi Uchino, Miki Uchino, Dogru Murat, Motoko Kawashima, Kazuo Tsubota, Shigeru Kinoshita; The Relationship between Ocular Surface Epithelial Damage and Tear Abnormalities: Osaka Study. Invest. Ophthalmol. Vis. Sci. 2013;54(15):939.

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Abstract

Purpose: In the pathophysiology of dry eye, tear abnormalities result in epithelial damage of the cornea and conjunctiva. The purpose of this present study was to investigate the relationship between ocular surface epithelial damage and tear abnormalities.

Methods: This study involved 279 eyes of 173 subjects (132 eyes of 72 males, 147 eyes of 101 females, mean age: 49 years) from normal subjects and dry eye patients. In all eyes, tear meniscus radius (TMR, mm), spread grade of the tear film lipid layer (SG, 1-4: 1 being the best), non-invasive breakup time (NIBUT, seconds), fluorescein breakup time (FBUT, seconds) and ocular surface epithelial damage (OSED) score (cornea: 15 points maximum, conjunctiva: 6 points maximum), Schirmer 1 test (ST1, mm) were measured, and the factors determining OSED score were investigated by multiple regression analysis in which the parameters were chosen using the stepwise procedure.

Results: The corneal OSED score was found to be determined by TMR, SG, and FBUT, and was described as: -0.363 - (3.997 x TMR) - (3.284 x SG) - (0.189 x FBUT) (R2=0.54, p<0.0001). The conjunctival OSED score was found to be determined by TMR, SG, and ST1, and was described as: 0.834 - (2.933 x TMR) + (1.320 x SG) - (0.025 x ST1) (R2=0.41, p<0.0001).

Conclusions: The findings of this study show that TMR and SG, factors related to aqueous tear volume and aqueous tear film thickness, respectively, were significantly related to both corneal and conjunctival epithelial damage, while FBUT, a factor related to tear film stability, was significantly related to the corneal OSED score and ST1, a factor related to lacrimal gland function, was related to the conjunctival OSED score.

Keywords: 486 cornea: tears/tear film/dry eye  
© 2013, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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