June 2013
Volume 54, Issue 15
ARVO Annual Meeting Abstract  |   June 2013
Change of tear meniscus by CL wearing and therapeutic effect of eye drop for the change
Author Affiliations & Notes
  • Hitoshi Watanabe
    Ophtalmology, Kansai Rosai Hospital, Amagasaki, Japan
  • Yukiko Nagahara
    Ophtalmology, Kansai Rosai Hospital, Amagasaki, Japan
  • Footnotes
    Commercial Relationships Hitoshi Watanabe, None; Yukiko Nagahara, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 964. doi:https://doi.org/
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      Hitoshi Watanabe, Yukiko Nagahara; Change of tear meniscus by CL wearing and therapeutic effect of eye drop for the change. Invest. Ophthalmol. Vis. Sci. 2013;54(15):964. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: Seventy to eighty percent of tear fluid over the ocular surface is present in upper and lower tear meniscus(TM). We investigated non-invasively the change of TM height(TMH) before and after CL wearing by anterior segment OCT and evaluated the effect of topical application of dry eye drug to improve TMH in CL wearer.

Methods: The objects are ten healthy normal volunteers; 8 males and 2 females aged from 33 to 50. TMH at the center of lower lid is determined by anterior segment OCT (CASIA®, Tomey) before and after wearing one day Acuvue® CL (J&J) . TMH is also investigated in 5, 15, 30, and 60 minutes after one drop of anti-dry eye drug. As eye drop, Diquafosol (DQS) is applied to one eye and artificial tear(AT) to the contralateral eye

Results: TMH is 2.2±0.4(×100μm) before and is significantly reduced to 1.3±0.3(×100μm) (59%) after CL wearing(p<0.0001). In AT treated eyes, TMH is significantly increased up to 15minutes but up to 60 minutes in DQS treated eyes. Moreover, value of TMH at 15, 30, and 60 minutes after topical application was 67±41, 52±36, and 34±37μm in DQS treated eyes and 33±21, 8±22, and -1±23μm in AT treated eyes. The value at each point of DQS treated eyes was significantly increased compared with that of AT treated eyes (P< 0.04, 0.005 and 0.03, respectively).

Conclusions: Dry eye in CL wearer has some aspect of tear deficiency by wearing CL and DQS is more effective to treat CL induced dry eye than artificial tear.

Keywords: 466 clinical (human) or epidemiologic studies: treatment/prevention assessment/controlled clinical trials • 479 cornea: clinical science  

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