June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
Racial Differences in Optic Nerve Head (ONH) and Laminar Surface Compliance in Normal Human Subjects
Author Affiliations & Notes
  • Brandon Smith
    Department of Ophthalmology, University of Alabama at Birmingham, Birmingham, AL
  • John Johnstone
    Department of Computer & Information Sciences, University of Alabama at Birmingham, Birmingham, AL
  • Kulawan Rojananuangnit
    Department of Ophthalmology, University of Alabama at Birmingham, Birmingham, AL
  • J Crawford Downs
    Department of Ophthalmology, University of Alabama at Birmingham, Birmingham, AL
  • Massimo Fazio
    Department of Ophthalmology, University of Alabama at Birmingham, Birmingham, AL
  • Cynthia Owsley
    Department of Ophthalmology, University of Alabama at Birmingham, Birmingham, AL
  • Mark Clark
    Department of Ophthalmology, University of Alabama at Birmingham, Birmingham, AL
  • Christopher Girkin
    Department of Ophthalmology, University of Alabama at Birmingham, Birmingham, AL
  • Footnotes
    Commercial Relationships Brandon Smith, None; John Johnstone, None; Kulawan Rojananuangnit, None; J Crawford Downs, None; Massimo Fazio, None; Cynthia Owsley, Genentech (F), Patent Licensed to: MacuLogix (P), Allergan (R); Mark Clark, None; Christopher Girkin, SOLX (F), Heidelberg Engineering (F)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 98. doi:
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    • Get Citation

      Brandon Smith, John Johnstone, Kulawan Rojananuangnit, J Crawford Downs, Massimo Fazio, Cynthia Owsley, Mark Clark, Christopher Girkin; Racial Differences in Optic Nerve Head (ONH) and Laminar Surface Compliance in Normal Human Subjects. Invest. Ophthalmol. Vis. Sci. 2013;54(15):98.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

To determine the demographic and ocular factors associated with change in cup depth (CD) and lamina cribrosa depth (LCD) resulting from acute IOP elevations in normal human subjects using Spectral Domain Ocular Coherence Tomography (SDOCT).

 
Methods
 

The ONHs of 21 patients were imaged with SDOCT at baseline and after IOP was raised ~15 mm Hg via ophthalmodynamometry for 1 minute. We compared CD and LCD from baseline to increased IOP as follows. Anatomic structures were delineated in 24 radial B-scans of the 48-scan OCT data set using custom software (Strouthidis et al., IOVS 2011). A plane containing the best-fit ellipse was computed using principal component analysis to define Bruch’s Membrane Opening (BMO), which was used as the anatomic measurement reference. A mesh was reconstructed from the point cloud for the anterior surface of lamina cribrosa (LC) and Internal Limiting Membrane (ILM). We then measured the distance from the BMO reference plane to the LC mesh and ILM on a uniform sampling grid to calculate the mean position of the LC surface (LCD) and the ILM (cup depth or CD). We analyzed the association of CD and LCD with increased IOP, age, CCT (central corneal thickness), and race (European Descent (ED) or African Descent (AD)).

 
Results
 

Significantly greater deepening of the ONH surface upon IOP elevation was independently associated with European heritage, the magnitude of IOP elevation, and thicker CCT. Change in LCD was not significant with any variable.

 
Conclusions
 

Individuals of African descent show reduced ONH surface compliance, while greater ONH surface compliance was seen with increasing IOP change and thicker CCT. No significant changes in laminar compliance were seen within SDOCT volumes with any factor.

  
Keywords: 629 optic nerve • 550 imaging/image analysis: clinical • 568 intraocular pressure  
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