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HARRY L. KNOPF, NEIL R. BLACKLOW, MORRIS I. GLASSMAN, WALTER L. CLINE, VERNON G. WONG; Antibody in Tears Following Intranasal Vaccination With Inactivated Virus III. Role of Tear and Serum Antibody in Experimental Vaccinia Conjunctivitis. Invest. Ophthalmol. Vis. Sci. 1971;10(10):760-769.
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© ARVO (1962-2015); The Authors (2016-present)
Fifteen rabbits were vaccinated with inactivated or live vaccinia virus by the intranasal or intradermal route, and then one eye was challenged with homologous lice virus. Two unvaccinated animals were similarly challenged and were used as controls. The animals were examined for clinical illness, virus shedding, and serologic changes in tears and serum. The results showed: (1) All animals shed vaccinia virus for at least one day. (2) Vaccination by any route resulted in decreased illness and virus shedding. (3) Animals with serum neutralizing antibody titers of ≥1/575 had the mildest illness by all parameters. (4) Tear antibody had no apparent effect on the illness or virus shedding. The importance of local mechanisms of protection and the application of this work to human conjunctival infections are discussed.
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