October 1971
Volume 10, Issue 10
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Articles  |   October 1971
Antibody in Tears Following Intranasal Vaccination With Inactivated Virus
Author Affiliations
  • HARRY L. KNOPF
    Laboratory of Vision Research, National Eye Institute, National Institute of Allergy and Infectious Diseases, and National Cancer Institute, National Institutes of Health, United States Department of Health, Education, and Welfare, Bethesda, Md. 20014
  • NEIL R. BLACKLOW
    Laboratory of Vision Research, National Eye Institute, National Institute of Allergy and Infectious Diseases, and National Cancer Institute, National Institutes of Health, United States Department of Health, Education, and Welfare, Bethesda, Md. 20014
  • MORRIS I. GLASSMAN
    Laboratory of Vision Research, National Eye Institute, National Institute of Allergy and Infectious Diseases, and National Cancer Institute, National Institutes of Health, United States Department of Health, Education, and Welfare, Bethesda, Md. 20014
  • WALTER L. CLINE
    Laboratory of Vision Research, National Eye Institute, National Institute of Allergy and Infectious Diseases, and National Cancer Institute, National Institutes of Health, United States Department of Health, Education, and Welfare, Bethesda, Md. 20014
  • VERNON G. WONG
    Laboratory of Vision Research, National Eye Institute, National Institute of Allergy and Infectious Diseases, and National Cancer Institute, National Institutes of Health, United States Department of Health, Education, and Welfare, Bethesda, Md. 20014
Investigative Ophthalmology & Visual Science October 1971, Vol.10, 760-769. doi:
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      HARRY L. KNOPF, NEIL R. BLACKLOW, MORRIS I. GLASSMAN, WALTER L. CLINE, VERNON G. WONG; Antibody in Tears Following Intranasal Vaccination With Inactivated Virus . Invest. Ophthalmol. Vis. Sci. 1971;10(10):760-769.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Fifteen rabbits were vaccinated with inactivated or live vaccinia virus by the intranasal or intradermal route, and then one eye was challenged with homologous lice virus. Two unvaccinated animals were similarly challenged and were used as controls. The animals were examined for clinical illness, virus shedding, and serologic changes in tears and serum. The results showed: (1) All animals shed vaccinia virus for at least one day. (2) Vaccination by any route resulted in decreased illness and virus shedding. (3) Animals with serum neutralizing antibody titers of ≥1/575 had the mildest illness by all parameters. (4) Tear antibody had no apparent effect on the illness or virus shedding. The importance of local mechanisms of protection and the application of this work to human conjunctival infections are discussed.

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