October 1971
Volume 10, Issue 10
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Articles  |   October 1971
Lymphocyte-Stimulating Activity of Ocular Tissues in Sympathetic Ophthalmia
Author Affiliations
  • GEORGE E. MARAK, Jr.
    Divisions of Ophthalmology and Rheumatic Diseases, Georgetown University Hospital, Ophthalmic Pathology Branch, Armed Forces Institute of Pathology, and Division of Nuclear Medicine, Walter Reed Army Institute of Research, Washington, D. C.
  • RAMON L. FONT
    Divisions of Ophthalmology and Rheumatic Diseases, Georgetown University Hospital, Ophthalmic Pathology Branch, Armed Forces Institute of Pathology, and Division of Nuclear Medicine, Walter Reed Army Institute of Research, Washington, D. C.
  • MERRILL C. JOHNSON
    Divisions of Ophthalmology and Rheumatic Diseases, Georgetown University Hospital, Ophthalmic Pathology Branch, Armed Forces Institute of Pathology, and Division of Nuclear Medicine, Walter Reed Army Institute of Research, Washington, D. C.
  • F. PAUL ALEPA
    Divisions of Ophthalmology and Rheumatic Diseases, Georgetown University Hospital, Ophthalmic Pathology Branch, Armed Forces Institute of Pathology, and Division of Nuclear Medicine, Walter Reed Army Institute of Research, Washington, D. C.
Investigative Ophthalmology & Visual Science October 1971, Vol.10, 770-774. doi:
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      GEORGE E. MARAK, RAMON L. FONT, MERRILL C. JOHNSON, F. PAUL ALEPA; Lymphocyte-Stimulating Activity of Ocular Tissues in Sympathetic Ophthalmia. Invest. Ophthalmol. Vis. Sci. 1971;10(10):770-774.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Blastogenic activity of ocular tissue extracts was elicited in lymphocyte cultures from peripheral blood of two of four patients with sympathetic ophthalmia. Retinal pigment epithelium, retina, and lens were mitogenic, while choroidal antigen was usually inactive. There was no evidence of cellular hypersensitivity to ocular tissue in several other forms of uveitis. The problems in interpreting these observations are discussed.

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