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P. GOURAS, R. E. CARR, R. D. GUNKEL; Retinitis Pigmentosa in Abetalipoproteinemia: Effects of Vitamin A. Invest. Ophthalmol. Vis. Sci. 1971;10(10):784-793.
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Two patients with abetalipoproteinemia are shown to develop a serum vitamin A deficiency when maintained on a normal diet. This deficiency leads to a severe impairment of vision, including abnormalities of dark adaptation and the electroretinogram which involve both rod and cone receptor systems. Massive oral doses of vitamin A can reverse these abnormalities. Cone function recovers more rapidly than rod function after vitamin A therapy. The relationship between vitamin A and the retinitis pigmentosa which these patients develop is discussed.
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