June 1971
Volume 10, Issue 6
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Articles  |   June 1971
"Steroid-Induced" Mydriasis and Ptosis
Author Affiliations
  • DAVID A. NEWSOME
    Clinical Branch, National Eye Institute, National Institutes of Health, United States Department of Health, Education and Welfare Bethesda, Md. 20014
  • VERNON G. WONG
    Clinical Branch, National Eye Institute, National Institutes of Health, United States Department of Health, Education and Welfare Bethesda, Md. 20014
  • THOMAS P. CAMERON
    Cancer Chemotherapy National Service Center, National Cancer Institute, National Institutes of Health, United States Department of Health, Education and Welfare Bethesda, Md. 20014
  • RICHARD R. ANDERSON
    Clinical Branch, National Eye Institute, National Institutes of Health, United States Department of Health, Education and Welfare Bethesda, Md. 20014
Investigative Ophthalmology & Visual Science June 1971, Vol.10, 424-429. doi:
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      DAVID A. NEWSOME, VERNON G. WONG, THOMAS P. CAMERON, RICHARD R. ANDERSON; "Steroid-Induced" Mydriasis and Ptosis. Invest. Ophthalmol. Vis. Sci. 1971;10(6):424-429.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Pupil size, width of palpebral fissure, and intraocular pressure were followed in rhesus monkeys monkeys before and after treatment of one eye with dexamethasone phosphate in a vehicle mixture (Decadron), the vehicle mixture alone, some individual constituents of the vehicle, and pure steroid--dexamethasone in saline. Decadron and the vehicle alone produced relative pupillary dilation and ptosis, but dexamethasone in saline did not. Pupil and lid changes were not accompanied by a rise in intraocular pressure. The mydriasis and ptosis appeared to be caused by a direct myopathic effect of the vehicle.

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