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DAVID A. NEWSOME, VERNON G. WONG, THOMAS P. CAMERON, RICHARD R. ANDERSON; "Steroid-Induced" Mydriasis and Ptosis. Invest. Ophthalmol. Vis. Sci. 1971;10(6):424-429.
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Pupil size, width of palpebral fissure, and intraocular pressure were followed in rhesus monkeys monkeys before and after treatment of one eye with dexamethasone phosphate in a vehicle mixture (Decadron), the vehicle mixture alone, some individual constituents of the vehicle, and pure steroid--dexamethasone in saline. Decadron and the vehicle alone produced relative pupillary dilation and ptosis, but dexamethasone in saline did not. Pupil and lid changes were not accompanied by a rise in intraocular pressure. The mydriasis and ptosis appeared to be caused by a direct myopathic effect of the vehicle.
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