October 1973
Volume 12, Issue 10
Articles  |   October 1973
Permeability Properties of the Ciliary Epithelium in Response to Prostaglandins
Author Affiliations
    W. K. Kellogg Research Laboratories, The Wilmer Institute, The Johns Hopkins University School of Medicine, Baltimore, Md. 21205
Investigative Ophthalmology & Visual Science October 1973, Vol.12, 752-758. doi:
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      KEITH GREEN; Permeability Properties of the Ciliary Epithelium in Response to Prostaglandins. Invest. Ophthalmol. Vis. Sci. 1973;12(10):752-758.

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The effects of prostaglandins E1, E2, and F2a were studied on both transport and flow conductivity in isolated rabbit ciliary body. All prostaglandins caused an increase in active transport and flow conductivity; the dose-dependency of these responses differed greatly, since transport was unaffected until concentrations of E1 and E2 were 10 µg per milliliter, whereas flow conductivity was increased at concentrations of 0.1 µg per milliliter; F2a increased flow conductivity at a concentration of 1.0 µg per milliliter and transport at 10 µg per milliliter. The descending order of potency in their ability to increase transport and flow conductivity was E1 ≃ E2 > F2a. Prior treatment of the tissues with polyphloretin phosphate prevented any prostaglandin response, but did not block the response once initiated. The results suggest that the increased permeability of the ciliary epithelium is the major factor in causing an increase in intraocular pressure seen after prostaglandin.


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