June 1973
Volume 12, Issue 6
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Articles  |   June 1973
Quantitative Determination of Choline Acetylase, Acetylcholine, and Acetylcholinesterase in the Developing Rabbit Cornea
Author Affiliations
  • RUFUS O. HOWARD
    Departments of Ophthalmology and Pharmacology, Yale University School of Medicine, New Haven, Conn. 06510
  • WILLIAM S. WILSON
    Departments of Ophthalmology and Pharmacology, Yale University School of Medicine, New Haven, Conn. 06510
  • BRENDAN J. DUNN
    Departments of Ophthalmology and Pharmacology, Yale University School of Medicine, New Haven, Conn. 06510
Investigative Ophthalmology & Visual Science June 1973, Vol.12, 418-425. doi:
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      RUFUS O. HOWARD, WILLIAM S. WILSON, BRENDAN J. DUNN; Quantitative Determination of Choline Acetylase, Acetylcholine, and Acetylcholinesterase in the Developing Rabbit Cornea. Invest. Ophthalmol. Vis. Sci. 1973;12(6):418-425.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Components of the cholinergic nervous system, acetyl choline (ACh), choline acetyltransferase (ChAc), and acetylcholinesterase (AChE) have been measured quantitatively in the developing rabbit cornea. ACh was detected initially approximately 10 days after birth, and subsequently increased in a nonlinear fashion to attain adult levels approximately 50 days after birth. ChAc was found initially about 12 days after birth, and increased in a linear fashion to reach adult levels approximately 56 days after birth. AChE activity was greater than adult levels just after birth, increased further to a peak activity 3 to 10 days after birth, then decreased to adult levels about 25 days after birth. The patterns of development of these three components in the rabbit cornea differs from that in the rabbit nervous system. It is inferred that a significant part of the corneal cholinergic components is unrelated to corneal innervation.

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