March 1974
Volume 13, Issue 3
Free
Articles  |   March 1974
The Cornea-Destroying Enzyme of Pseudomonas Aeruginosa
Author Affiliations
  • STUART I. BROWN
    Cornea Service and Research Laboratory, New York Hospital-Cornell University Medical Center, 525 E. 68 St., New York, N. Y. 10021
  • STEPHEN E. BLOOMFIELD
    Cornea Service and Research Laboratory, New York Hospital-Cornell University Medical Center, 525 E. 68 St., New York, N. Y. 10021
  • WAI-FONG I. TAM
    Cornea Service and Research Laboratory, New York Hospital-Cornell University Medical Center, 525 E. 68 St., New York, N. Y. 10021
Investigative Ophthalmology & Visual Science March 1974, Vol.13, 174-180. doi:
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      STUART I. BROWN, STEPHEN E. BLOOMFIELD, WAI-FONG I. TAM; The Cornea-Destroying Enzyme of Pseudomonas Aeruginosa. Invest. Ophthalmol. Vis. Sci. 1974;13(3):174-180.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

The harvest media from five strains of Pseudomonas aeruginosa collected from severe clinical infections did not contain a collagenase. Instead, an enzyme was isolated that could degrade the ground substance of the cornea. Partial purification of this enzyme indicated that it was the only enzyme in the harvest media that could destroy the rabbit cornea after intralamellar injection. Na2EDTA completely inhibited this enzyme.

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