The Arterial Pressure Dependency of the Increased Aqueous Humor Formation Induced by Ach+eserine

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Abstract

The magnitude of the increased rate of formation of aqueous humor produced by Ach+eserine is dependent and proportional to the arterial perfusate head pressure. Because of this, it may be assumed that the mechanism of the Ach+eserine response is due to an increase in ultrafiltration. It is suggested that the increase in ultrafiltration is brought about by a constriction of efferent ciliary process blood vessels.

It has recently been reported that the administration of acetylcholine plus eserine (Ach+eserine) to enucleated, arterially perfused cat eyes produces a marked increase in the rate of aqueous humor formation.¹ The present study was undertaken to determine the vascular pressure dependency of this increased aqueous humor formation rate.