March 1974
Volume 13, Issue 3
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Articles  |   March 1974
Immunopathogenesis of LCM Virus-Induced Uveitis: The Role of T Lymphocytes
Author Affiliations
  • URIEL TICHO
    Wilmer Institute and School of Hygiene and Public Health, Johns Hopkins Medical Institutions, Baltimore, Md.; Hadassah University Hospital, Jerusalem, Israel
  • ARTHUR M. SILVERSTEIN
    Wilmer Institute and School of Hygiene and Public Health, Johns Hopkins Medical Institutions, Baltimore, Md.
  • GERALD A. COLE
    Wilmer Institute and School of Hygiene and Public Health, Johns Hopkins Medical Institutions, Baltimore, Md.
Investigative Ophthalmology & Visual Science March 1974, Vol.13, 229-231. doi:
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      URIEL TICHO, ARTHUR M. SILVERSTEIN, GERALD A. COLE; Immunopathogenesis of LCM Virus-Induced Uveitis: The Role of T Lymphocytes. Invest. Ophthalmol. Vis. Sci. 1974;13(3):229-231.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

The immunopathologic uveitis and panophthalmitis produced by intraocular injection of lymphocytic choriomeningitis virus in mice can be abrogated by immunosuppression with Cytoxan. Ocular inflammation is triggered in the resulting chronic virus carriers following adoptive transfer of immune spleen cells. This report demonstrates that destruction of the thymus-dependent (T cell) class of lymphocytes in the transferred cell population, by treatment with anti-θ antibody and complement, prevents the induction of ocular pathology. The residual cells do form humoral antibody and mediate a degree of virus clearance in the host, although without evidence of disease. Thus, this model of virus-induced immunopathology is clearly based upon a mechanism of cellular immunity.

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