February 1976
Volume 15, Issue 2
Articles  |   February 1976
The biphasic intraocular pressure response of rabbits to epinephrine.
Investigative Ophthalmology & Visual Science February 1976, Vol.15, 119-127. doi:
  • Views
  • PDF
  • Share
  • Tools
    • Alerts
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      M E Langham, G K Krieglstein; The biphasic intraocular pressure response of rabbits to epinephrine.. Invest. Ophthalmol. Vis. Sci. 1976;15(2):119-127.

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

  • Supplements
This content is PDF only. Please click on the PDF icon to access.

A study has been made of the pupillary and intraocular pressure responses of conscious rabbits to daily topical applications of submaximal doses of epinephrine. On the first day, epinephrine caused rapid pupil dilation which preceded a prolonged -ecrease of intraocular pressure. On the second and subsequent days, the application of the same dose of epinephrine increased the duration of the pupillary response and caused a biphasic pressure response in all treated eyes; an initial increase of intraocular pressure lasting two to four hours followed by decrease of intraocular pressure below the initial value which lasted for more than twenty-four hours. The beta-receptor antagonist, propranolol, and the alpha-receptor antagonist, phenoxybenzamine, caused small and large reductions, respectively, in the hypertensive response to epinephrine. Phenoxybenzamine, but not propranolol, also inhibited the pupil dilation and the hypotensive response to epinephrine. Topical administration of phenoxybenzamine strongly inhibited the hypertensive response to epinephrine but left unaffected the pupillary response.


This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.