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Abstract
The ocular effect of fenoprofen, a new nonsteroidal anti-inflammatory agent, was studied. The elevations of intraocidar pressure and aqueous humor protein induced by 5 per cent arachidonic acid applied to rabbit eyes were partially blocked by topical pretreatment with 2 per cent fenoprofen. Fenoprofen 2 per cent did not prevent the elevation of intraocular pressure produced by 3 µg of prostaglandin Et. The results implied that fenoprofen inhibits the in vivo synthesis or release of ocular prostaglandin.