December 1976
Volume 15, Issue 12
Articles  |   December 1976
Niemann-Pick disease-like inclusions caused by a hypocholesteremic agent.
Investigative Ophthalmology & Visual Science December 1976, Vol.15, 1022-1027. doi:
  • Views
  • PDF
  • Share
  • Tools
    • Alerts
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      M Sakuragawa; Niemann-Pick disease-like inclusions caused by a hypocholesteremic agent.. Invest. Ophthalmol. Vis. Sci. 1976;15(12):1022-1027. doi:

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

  • Supplements
This content is PDF only. Please click on the PDF icon to access.

AY9944, an inhibitor of cholesterol biosynthesis, was injected into albino rats and the ocular tissue was studied by light and electron microscopy. Abundant lamellar inclusion bodies accumulated in various cells of the eye, especially in the ganglion cells of the retina and glial cells of the optic nerve. Prolonged administration of this drug resulted in degeneration of retinal ganglion cells and oligodendroglial cells of the optic nerve. Micro-organelles of the inclusion body-laden cells were otherwise normal in their appearance. The electron microscopic appearance of these inclusion bodies and their distribution in the ocular tissues closely resembled those of Niemann-Pick diseasees.


This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.