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R Bensinger, D H Shin, M A Kass, S M Podos, B Becker; Pilocarpine ocular inserts.. Invest. Ophthalmol. Vis. Sci. 1976;15(12):1008-1010.
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Pilocarpine was administered to a selected group of ocular hypertensive subjects in the form of a synthetic biosoluble matrix inserted into the conjunctival cul-de-sac. Satisfactory lowering of the intraocular pressure resulted, with a minimum of subject intolerance. The decreased pressure response was significant in some cases for greater than 24 hours. Drug delivery by soluble inserts offers promise as a convenient and effective mode of therapy.
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