March 1976
Volume 15, Issue 3
Articles  |   March 1976
Anti-herpes activity of adenine arabinoside monophosphate.
Investigative Ophthalmology & Visual Science March 1976, Vol.15, 196-199. doi:
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      J D Trobe, Y Centifanto, Z S Zam, E Varnell, H E Kaufman; Anti-herpes activity of adenine arabinoside monophosphate.. Invest. Ophthalmol. Vis. Sci. 1976;15(3):196-199.

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      © ARVO (1962-2015); The Authors (2016-present)

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Adenine arabinoside monophosphate (Ara-AMP) demonstrated antiviral activity equivalent to adenine arabinoside (Ara-A) against herpesvirus Types 1 and 2 in tissue culture. Against established herpes virus Type 1 epithelial keratitis in rabbits, Ara-AMP 2 per cent was comparable in efficacy to Ara-A 3 per cent, and Ara-AMP 20 per cent was superior to Ara-A 3 per cent. These results are especially significant in that Ara-A's high solubility will permit (1) more concentrated formulations to be presented topically and (2) adequate absorption by parenteral routes with smaller fluid loads than required for Ara-A.


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